FGFR3

fibroblast growth factor receptor 3

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.

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Products

Antibodies (53)

Proteins (19)

ELISA Kits (10)

Type

Cell-Based (1)

Over-Expression Lysate (2)

Primary (53)

Recombinant (17)

Sandwich (8)

Sandwich CLIA (1)

Target

FGFR3 (82)

Reactivity

Human (52)

Mouse (31)

Rat (9)

Bovine (1)

Chicken (1)

Dog (1)

Monkey (1)

Pig (1)

Porcine (1)

Rabbit (1)

Application

IHC (27)

IHC-P (6)

WB (42)

Flo (1)

ELISA (28)

IF (3)

IP (1)

Peptide-ELISA (2)

Host

rabbit (46)

mouse (7)

Isotype

IgG (28)

IgG1 (4)

IgG2a (3)

Clonality

monoclonal mc (8)

polyclonal pc (45)

Clone

042 (1)

07 (1)

1E3F9 (1)

2H10B4 (1)

OTI1B10 (2)

OTI1G10 (2)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (2)

96-Well Strip Plate (7)

APC (1)

APC Conjugated (3)

Azide-free (2)

Biotin Conjugated (4)

Carrier-free (2)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (3)

Preservative Free (2)

Unconjugated (33)

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Epitope

aa166-375 (8)

aa468-495 (7)

aa776-806 (7)

aa23-375 (3)

100-180 aa, Internal (1)

Internal (1)

N-Terminus (1)

aa131-180 (1)

aa449-482 (1)

Publications

No (81)

Yes (1)

Sample Type

Adherent Cell Cultures (1)

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (3)

Tag

6His, C-terminus (2)

6His, N-terminus (2)

6His-B2M, N-terminus (1)

Fc (1)

Fc, C-terminus (2)

GST, N-terminus (1)

His (2)

His,C-terminus (1)

His-Fc (1)

His-T7 (1)

Myc-DDK (Flag) (3)

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Species

Human (16)

Mouse (2)

Source

293T Cells (1)

CHO Cells (1)

E. coli (3)

HEK 293 Cells (3)

Human (1)

Human Cells (4)

Mammalian Cells (3)

Wheat Germ Extract (1)

Yeast (2)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (9)

Biologically Active

Biologically active (2)

Select

FGFR3 Antibody LS-C201110

Antibody:

FGFR3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

0.1 mg/$460

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FGFR3 Antibody (N-Terminus) LS-C66140

Antibody:

FGFR3 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

100 µl/$553

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FGFR3 Antibody (aa468-495) LS-C164387

Antibody:

FGFR3 Rabbit anti-Mouse Polyclonal (aa468-495) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

FGFR3 Antibody (Internal) LS-C352196

Antibody:

FGFR3 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Pig, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

Select

FGFR3 Antibody (aa166-375) LS-C293910

Antibody:

FGFR3 Rabbit anti-Human Polyclonal (aa166-375) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

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FGFR3 Antibody (aa166-375, APC) LS-C717226

Antibody:

FGFR3 Rabbit anti-Human Polyclonal (aa166-375) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325

• Unconjugated
• APC

• Unconjugated
• APC

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Human FGFR3 Protein (Recombinant 6His, C-terminus) (Glu23-Gly375) - LS-G51899

Source:

Human Cells

Tag:

6His, C-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

39kD

Price:

10 µg/$277; 50 µg/$395; 500 µg/$1,262; 1 mg/$1,627

Select

FGFR3 Antibody (aa23-375, clone OTI1B10) LS-C336304

Antibody:

FGFR3 Mouse anti-Human Monoclonal (aa23-375) (OTI1B10) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$450

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FGFR3 Antibody (clone 2H10B4) LS-C669255

Antibody:

FGFR3 Mouse anti-Human Monoclonal (2H10B4) Antibody

Reactivity:

Human

Applications:

ELISA, Flo

Format:

Unconjugated

Price:

100 µl/$459

Select

FGFR3 Antibody (aa131-180) LS-C118448

Antibody:

FGFR3 Rabbit anti-Human Polyclonal (aa131-180) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

FGFR3 Antibody (aa776-806) LS-C97523

Antibody:

FGFR3 Rabbit anti-Human Polyclonal (aa776-806) Antibody

Applications:

IHC, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

FGFR3 Antibody LS-C800283

Antibody:

FGFR3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

Human FGFR3 Protein (Recombinant His) (aa23-375) - LS-G22922

Source:

Yeast

Tag:

His

Molecular Weight:

40.1 kD

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

Select

Mouse FGFR3 (Sandwich ELISA) ELISA Kit - LS-F8713

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$818

Select

FGFR3 Antibody (aa468-495) LS-C321382

Antibody:

FGFR3 Rabbit anti-Mouse Polyclonal (aa468-495) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

FGFR3 Antibody (aa468-495, Azide-free, HRP) LS-C214248

(4.0) Rating

(1) Publication(s)

Antibody:

FGFR3 Rabbit anti-Mouse Polyclonal (aa468-495) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• HRP, Azide-free

• Unconjugated
• HRP, Azide-free

Select

FGFR3 Antibody (clone 042, Preservative Free) LS-C819327

Antibody:

FGFR3 Rabbit anti-Mouse Monoclonal (Preservative Free) (042) Antibody

Reactivity:

Mouse

Applications:

ELISA

Format:

Unconjugated, Preservative Free

Price:

20 µl/$271; 100 µl/$412

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Human FGFR3 Protein (Recombinant 6His, N-terminus) (aa397-806) - LS-G57165

Source:

Yeast

Tag:

6His, N-terminus

Price:

100 µg/$446; 20 µg/$336; 1 mg/$1,460

Select

Human FGFR3 Protein (Recombinant 6His, N-terminus) (aa23-375) - LS-G20739

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

42.2 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

FGFR3 Antibody (aa776-806) LS-C327389

Antibody:

FGFR3 Rabbit anti-Human Polyclonal (aa776-806) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

FGFR3 Antibody (clone 1E3F9) LS-C669296

Antibody:

FGFR3 Mouse anti-Human Monoclonal (1E3F9) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$459

Select

FGFR3 Antibody LS-C408205

Antibody:

FGFR3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

FGFR3 Antibody (Biotin) LS-C317436

Antibody:

FGFR3 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

FGFR3 Antibody LS-C486392

Antibody:

FGFR3 Rabbit anti-Mouse Polyclonal Antibody

Reactivity:

Mouse

Applications:

ELISA

Format:

Unconjugated

Price:

20 µl/$271; 100 µl/$412

Select

FGFR3 Antibody (clone OTI1G10) LS-C175535

Antibody:

FGFR3 Mouse anti-Human Monoclonal (OTI1G10) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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