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Endothelin 3 / EDN3
endothelin 3
Endothelin 3 / EDN3 is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | endothelin 3 |
| Family/Subfamily: | Hormone , not assigned-Hormone |
| Synonyms: | EDN3, Endothelin-3, ET3, Endothelin 3, Preproendothelin-3, WS4B, ET-3, HSCR4, PPET3 |
| Target Sequences: | NM_000114 NP_000105.1 P14138 |
Publications (1)
1
B-lymphocyte-intrinsic and -extrinsic defects in secretory immunoglobulin A production in the neural crest-conditional deletion of endothelin receptor B model of Hirschsprung-associated enterocolitis. Giuliana Medrano, Frederic Cailleux, Peihong Guan, Korah Kuruvilla, Amanda J Barlow-Anacker, Ankush Gosain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 June;33:7615-7624. [Full Text Article]
[PubMed:30908942]
[PMC:PMC6529339]
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Endothelin 3 / EDN3 Mouse anti-Human Monoclonal (2A6-2A4) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Rat, Pig, Human
IF, IHC
Unconjugated
50 µl/$572
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
1.56 - 100 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Endothelin 3 / EDN3 Mouse anti-Human Monoclonal (aa17-238) (OTI3E10) Antibody
Human
IHC
Unconjugated
100 µl/$434
Endothelin 3 / EDN3 Mouse anti-Human Monoclonal (aa17-238) (Carrier-free) (OTI3E10) Antibody
Human
IHC
Unconjugated, Carrier-free
100 µg/$511
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Rabbit, Pig, Human
ELISA
Unconjugated
400 µg/$878
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$749
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa168-197) Antibody
Human
WB
Unconjugated
400 µl/$393
Endothelin 3 / EDN3 Rabbit anti-Human Polyclonal (aa1-217) Antibody
Human
WB
Unconjugated
100 µl/$450
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