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Anti-DRD4 / Dopamine Receptor D4 Antibody (3rd Extracellular Domain) LS-C22935

Ordering

Wt. Vol. Conc. Price
50 µg - - $530

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Rabbit Polyclonal (IgG) to Mouse DRD4 / Dopamine Receptor D4
Mouse
Western blot, ELISA
Unconjugated

Details

Mouse DRD4 / Dopamine Receptor D4
Rabbit
Mouse (tested or 100% immunogen sequence identity)
IgG Polyclonal
Affinity purified

Applications

Western blot (1 - 10 µg/ml), ELISA (0.5 - 1 µg/ml)

Specificity and Use

DRD4 / Dopamine Receptor D4 antibody was raised against a 10 amino acid peptide sequence from the mouse D4 receptor within the 3rd extracellular domain.
3rd Extracellular Domain
Specific for Dopamine Receptor D4. Mouse Dopamine receptor D4 is a 387 aa, G-protein coupled and transmembrane receptor protein. The immunogen peptide shows no significant homology with other dopamine receptors (D1, D2, D3 or D5). Species Reactivity: the immunogen peptide shows sequence homology of 90% with rat and human D4 receptors.
Western blot: 1-10 ug/ml (Chemiluminescence technique). Approximately 100-400 ug of membrane protein/lane should be loaded to visualize the receptor band. Immunohistochemistry: Has not been tested. It is recommended that the antibody be used at 1-20 ug/ml on paraformaldehyde fixed sections. ELISA: 0.5-1.0 ug/ml (1 ug/ml immunogen peptide/well).

Packaging

PBS, pH 7.4, 0.1% BSA, 0.02% sodium merthiolate.
For research use only.

About DRD4 / Dopamine Receptor D4

P21917 NM_000797 NP_000788.2

DRD4 Antibody, D(4) dopamine receptor Antibody, D4DR Antibody, D(2C) dopamine receptor Antibody, D4 dopamine receptor Antibody, Dopamine receptor D4 Antibody, Dopamine 4 receptor Antibody, Dopamine D4 receptor Antibody

Dopamine Receptor D4 (DRD4), a Dopamine Receptor, has been suggested to affect personality, substance dependence, cognition, and emotion. DRD4 binds the antipsychotic medications clozapine and spiperone. DRD4 knock-out mice are anatomically normal but display altered locomotion and sensitivity to drugs such as clozapine, cocaine, and others.

Requested From: United States
Date Requested: 8/29/2014

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