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DNMT / DNMT1

DNA (cytosine-5-)-methyltransferase 1

Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9.

Gene Name:	DNA (cytosine-5-)-methyltransferase 1
Family/Subfamily:	C5-methyltransferase
Synonyms:	DNMT1, AIM, CXXC finger protein 9, CXXC9, DNA methyltransferase 1, DNMT, DNA methyltransferase HsaI, DNA MTase HsaI, HSN1E, M.HsaI, MCMT
Target Sequences:	NM_001379 NP_001370.1 P26358

Publications (13)

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B. Nature. 2002 416:552-6. (WB; Human) [PubMed:11932749]

An essential role for DNA methyltransferase DNMT3B in cancer cell survival. Beaulieu N, Morin S, Chute IC, Robert MF, Nguyen H, MacLeod AR. The Journal of biological chemistry. 2002 277:28176-81. (WB; Human) [PubMed:12015329]

DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, MacLeod AR. Nature genetics. 2003 33:61-5. (WB; Human) [PubMed:12496760]

Differential expression of DNA-methyltransferases in drug resistant murine neuroblastoma cells. Qiu YY, Mirkin BL, Dwivedi RS. Cancer detection and prevention. 2002 26:444-53. (ICC, WB; Mouse) [PubMed:12507229]

Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication. Estve PO, Chin HG, Smallwood A, Feehery GR, Gangisetty O, Karpf AR, Carey MF, Pradhan S. Genes & development. 2006 20:3089-103. [PubMed:17085482] [PMC:PMC1635145]

Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model. Morey Kinney SR, Smiraglia DJ, James SR, Moser MT, Foster BA, Karpf AR. Molecular cancer research : MCR. 2008 6:1365-74. (WB; Mouse) [PubMed:18667590] [PMC:PMC2835734]

Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL. Kaminskyy VO, Surova OV, Vaculova A, Zhivotovsky B. Carcinogenesis. 2011 32:1450-8. [PubMed:21771726]

DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation. Shaknovich R, Cerchietti L, Tsikitas L, Kormaksson M, De S, Figueroa ME, Ballon G, Yang SN, Weinhold N, Reimers M, Clozel T, Luttrop K, Ekstrom TJ, Frank J, Vasanthakumar A, Godley LA, Michor F, Elemento O, Melnick A. Blood. 2011 118:3559-69. [PubMed:21828137] [PMC:PMC3186332]

Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases. Selvakumar T, Gjidoda A, Hovde SL, Henry RW. The Journal of biological chemistry. 2012 287:7039-50. (WB; Human) [PubMed:22219193] [PMC:PMC3293528]

Insufficient maintenance DNA methylation is associated with abnormal embryonic development. Yin LJ, Zhang Y, Lv PP, He WH, Wu YT, Liu AX, Ding GL, Dong MY, Qu F, Xu CM, Zhu XM, Huang HF. BMC medicine. 2012 10:26. (IHC, WB; Mouse, Human) [PubMed:22413869] [PMC:PMC3355050]

Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis. Kristensen DG, Nielsen JE, Jørgensen A, Skakkebæk NE, Rajpert-De Meyts E, Almstrup K. British journal of cancer. 2014 110:668-78. (WB, ELISA; Human) [Full Text Article] [PubMed:24292451] [PMC:PMC3915112] Related Antibodies: LS-B800.

Structural equation modelling analysis determining causal role among methyltransferases, methylation, and apoptosis during human pregnancy and abortion. Nishat Fatima, Syed Habeeb Ahmed, S S Chauhan, Owais Mohammad, Syed Mohd Fazlur Rehman. Scientific reports. 2020 July;10:12408. [Full Text Article] [PubMed:32709893] [PMC:PMC7381664] Related Antibodies: LS-B4353.

Black raspberries demethylate Sfrp4, a WNT pathway antagonist, in rat esophageal squamous cell papilloma. Yi-Wen Huang, Fei Gu, Alan Dombkowski, Li-Shu Wang, Gary D Stoner. Molecular carcinogenesis. 2016 November;55:1867-1875. [Full Text Article] [PubMed:27696538] Related Antibodies: LS-B4353.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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