DDB2

damage-specific DNA binding protein 2, 48kDa

Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.

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Products

Antibodies (46)

Proteins (7)

Type

Over-Expression Lysate (2)

Primary (46)

Recombinant (5)

Target

DDB2 (53)

Reactivity

Human (38)

Mouse (24)

Rat (3)

Chimpanzee (3)

Gibbon (3)

Monkey (4)

Application

IHC (3)

IHC-P (1)

WB (42)

DB (3)

ELISA (5)

ICC (2)

IF (3)

IP (1)

Peptide-ELISA (1)

Host

rabbit (40)

mouse (6)

Isotype

IgG (16)

IgG1 (3)

IgG2b,k (1)

Clonality

monoclonal mc (7)

polyclonal pc (39)

Clone

11C1023 (1)

1F11 (1)

2246C4a (2)

OTI2E12 (2)

Format

APC (2)

APC Conjugated (3)

Biotin Conjugated (5)

Carrier-free (1)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (3)

Preservative Free (1)

Unconjugated (21)

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Epitope

aa166-383 (8)

aa212-407 (8)

aa351-400 (4)

aa1-250 (2)

aa1-115 (1)

aa419-427 (1)

Publications

No (52)

Yes (1)

Tag

6His, N-terminus (1)

GST (1)

GST, N-terminus (2)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (3)

Purification

Purified (1)

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DDB2 Antibody (aa419-427) LS-C18970

(4.1) Rating

(2) Publication(s)

Antibody:

DDB2 Rabbit anti-Human Polyclonal (aa419-427) Antibody

Reactivity:

Human

Applications:

DB, ELISA, IHC, IP, WB

Format:

Unconjugated

Price:

100 µl/$567

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DDB2 Antibody LS-C331725

Antibody:

DDB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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DDB2 Antibody (clone 11C1023) LS-C183822

Antibody:

DDB2 Rabbit anti-Human Monoclonal (11C1023) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$688

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DDB2 Antibody (clone 2246C4a) LS-C342450

Antibody:

DDB2 Mouse anti-Human Monoclonal (2246C4a) Antibody

Reactivity:

Human

Applications:

DB, ICC, IF, WB

Format:

Unconjugated

Price:

100 µg/$486

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Human DDB2 Protein (Recombinant 6His, N-terminus) (aa166-383) - LS-G11997

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

28.6 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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DDB2 Antibody LS-C665019

Antibody:

DDB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$331

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DDB2 Antibody (clone 2246C4a) LS-C184404

Antibody:

DDB2 Mouse anti-Human Monoclonal (2246C4a) Antibody

Reactivity:

Human

Applications:

DB, ICC, WB

Format:

Unconjugated

Price:

100 µg/$965

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DDB2 Antibody LS-C192754

Antibody:

DDB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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DDB2 Antibody (clone 1F11) LS-C197030

Antibody:

DDB2 Mouse anti-Human Monoclonal (1F11) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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DDB2 Antibody LS-C781644

Antibody:

DDB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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DDB2 Antibody LS-C671936

Antibody:

DDB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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DDB2 Antibody LS-C809168

Antibody:

DDB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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DDB2 Antibody (aa166-383) LS-C314463

Antibody:

DDB2 Rabbit anti-Human Polyclonal (aa166-383) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299; 200 µl/$336; 500 µl/$462; 1 ml/$525; 2 ml/$677; 5 ml/$1,136

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DDB2 Antibody (aa166-383, HRP) LS-C707109

Antibody:

DDB2 Rabbit anti-Human Polyclonal (aa166-383) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$325; 200 µl/$374; 500 µl/$537; 1 ml/$629; 2 ml/$863; 5 ml/$1,429

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DDB2 Antibody (aa166-383, Biotin) LS-C684348

Antibody:

DDB2 Rabbit anti-Human Polyclonal (aa166-383) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$307; 200 µl/$349; 500 µl/$487; 1 ml/$556; 2 ml/$745; 5 ml/$1,209

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DDB2 Antibody (aa166-383, FITC) LS-C690577

Antibody:

DDB2 Rabbit anti-Human Polyclonal (aa166-383) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$334; 200 µl/$387; 500 µl/$562; 1 ml/$677; 2 ml/$914; 5 ml/$1,539

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DDB2 Antibody (aa166-383, Cy3) LS-C698090

Antibody:

DDB2 Rabbit anti-Human Polyclonal (aa166-383) (Cy3) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$387; 200 µl/$462; 500 µl/$774; 1 ml/$929; 2 ml/$1,189; 5 ml/$2,199

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3

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DDB2 Antibody LS-C64562

Antibody:

DDB2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$786

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DDB2 Antibody (aa212-407) LS-C373930

Antibody:

DDB2 Rabbit anti-Mouse Polyclonal (aa212-407) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161

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DDB2 Antibody (aa1-250, clone OTI2E12) LS-C795597

Antibody:

DDB2 Mouse anti-Human Monoclonal (aa1-250) (OTI2E12) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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DDB2 Antibody (aa1-250, clone OTI2E12, Carrier-free) LS-C799731

Antibody:

DDB2 Mouse anti-Human Monoclonal (aa1-250) (Carrier-free) (OTI2E12) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

DDB2 Antibody LS-C310101

Antibody:

DDB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$749

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DDB2 Antibody LS-C490430

Antibody:

DDB2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$575

Select

DDB2 Antibody (aa1-115) LS-C407969

Antibody:

DDB2 Rabbit anti-Human Polyclonal (aa1-115) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

Select

DDB2 Antibody (aa351-400) LS-C135730

Antibody:

DDB2 Rabbit anti-Human Polyclonal (aa351-400) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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