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Complement C3
complement component 3
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates.Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes.
| Gene Name: | complement component 3 |
| Synonyms: | C3, AHUS5, ARMD9, Complement component C3, CPAMD1, Complement C3, ASP, Complement component 3 |
| Target Sequences: | NM_000064 NP_000055.2 P01024 |
Publications (8)
1
Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia. Wang W, Irani RA, Zhang Y, Ramin SM, Blackwell SC, Tao L, Kellems RE, Xia Y. Hypertension. 2012 60:712-21. (IHC; Mouse)
[Full Text Article]
[PubMed:22868393]
[PMC:PMC4131740]
Related Antibodies: LS-C22283.
2
Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites. Braig D, Nero TL, Koch HG, Kaiser B, Wang X, Thiele JR, Morton CJ, Zeller J, Kiefer J, Potempa LA, Mellett NA, Miles LA, Du XJ, Meikle PJ, Huber-Lang M, Stark GB, Parker MW, Peter K, Eisenhardt SU. Nature communications. 2017 8:14188. (Flo; Human)
[Full Text Article]
[PubMed:28112148]
[PMC:PMC5264208]
Related Antibodies: LS-C62856.
3
Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases. Fridkis-Hareli M, Storek M, Mazsaroff I, Risitano AM, Lundberg AS, Horvath CJ, Holers VM. Blood. 2011 118:4705-13. (Flo; Human)
[Full Text Article]
[PubMed:21860027]
Related Antibodies: LS-C34556.
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(110)
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(14)
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(31)
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(1)
Target
Complement C3
(165)
Reactivity
Human
(82)
Mouse
(29)
Rat
(20)
Bovine
(2)
Canine
(1)
Chicken
(3)
Dog
(2)
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(2)
Monkey
(2)
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(12)
Rabbit
(3)
Sheep
(1)
Application
IHC
(31)
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(11)
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(10)
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(75)
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(22)
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(55)
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(56)
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(39)
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(3)
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(25)
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(30)
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(2)
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(2)
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(1)
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(3)
IgG2b,k
(2)
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monoclonal mc
(40)
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(70)
Clone
053A-514.3.1.4
(1)
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12 x 8-Well Microstrips
(2)
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(7)
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(29)
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(4)
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(4)
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(13)
Cy3 Conjugated
(4)
Cy7 Conjugated
(4)
FITC Conjugated
(16)
HRP Conjugated
(10)
PE Conjugated
(9)
Serum
(1)
Unconjugated
(50)
Epitope
aa1322-1661
(9)
aa23-300
(8)
aa966-1313
(8)
aa1314-1663
(5)
aa965-1303
(3)
aa1000-1326
(2)
C-Terminus
(1)
aa1580-1592
(1)
aa681-693
(1)
Publications
No
(157)
Yes
(8)
Sample Type
Cell Culture
(1)
Cell Culture Supernatants
(4)
Cell Supernatant
(2)
Milk
(1)
Plasma
(36)
Saliva
(2)
Serum
(36)
Tissue Homogenates
(11)
Urine
(2)
Tag
6His, N-terminus
(1)
6His-SUMO, N-terminus
(1)
GST, N-terminus
(1)
His
(4)
His-S
(1)
His-SUMO
(1)
Myc-DDK (Flag)
(3)
Species
Cow
(1)
Human
(8)
Mouse
(4)
Pig
(1)
Rat
(2)
Source
293T Cells
(1)
E. coli
(11)
HEK 293 Cells
(2)
Wheat Germ Extract
(1)
Yeast
(1)
Purification
Purified
(3)
Low Endotoxin Level
Low endotoxin level
(4)
Complement C3 Mouse anti-Human Monoclonal (5F9) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Complement C3 Rat anti-Mouse Monoclonal (11H9) Antibody
Mouse
ELISA, Flo, IHC, IHC-Fr, IP, WB
Unconjugated
100 µg/$919
Complement C3 Mouse anti-Human Monoclonal (6C9) Antibody
Human
ELISA, Flo
Unconjugated
250 µg/$478
Complement C3 Mouse anti-Human Monoclonal (PE) (6C9) Antibody
Mouse, Human
ELISA, Flo
PE Conjugated
50 µg/$382
Complement C3 Rabbit anti-Pig Polyclonal (aa23-300) Antibody
Pig
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,324
Complement C3 Goat anti-Human Polyclonal (aa1580-1592) Antibody
Human, Monkey
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µg/$485
Complement C3 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Complement C3 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$294; 100 µg/$360
Complement C3 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
Complement C3 Mouse anti-Mouse Monoclonal (Biotin) (10C7) Antibody
Mouse, Human
ELISA, Flo
Biotin Conjugated
100 µg/$380
Complement C3 Mouse anti-Human Monoclonal (Biotin) (6C9) Antibody
Mouse, Human
ELISA, Flo
Biotin Conjugated
100 µg/$380
Complement C3 Mouse anti-Human Monoclonal (PE) (10C7) Antibody
Human
ELISA, Flo
PE Conjugated
50 µg/$383
Complement C3 Mouse anti-Human Monoclonal (FITC) (6C9) Antibody
Mouse, Human
ELISA, Flo
FITC Conjugated
100 µg/$402
Complement C3 Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse
ELISA, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
Complement C3 Mouse anti-Human Monoclonal (FITC) (10C7) Antibody
Human
Flo
FITC Conjugated
100 µg/$402
Complement C3 Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
Sandwich
96-Well Microplate
Human
7.81 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$724
Sandwich
96-Well Microplate
Rat
7.81 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
Sandwich
96-Well Microplate
Mouse
3.13 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
Sandwich
96-Well Strip Plate
Rat
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
Sandwich
96-Well Microplate
Pig
7.81 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$728
Sandwich
96-Well Strip Plate
Human
0.02 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture, Milk, Plasma, Saliva, Serum, Urine
1 Plate/$690
Sandwich
96-Well Strip Plate
Mouse
0.2 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$896
Sandwich
96-Well Strip Plate
Human
7.8 - 500 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$537
Sandwich
96-Well Strip Plate
Mouse
6.25 - 400 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
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