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CBLC
Cbl proto-oncogene C, E3 ubiquitin protein ligase
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
| Gene Name: | Cbl proto-oncogene C, E3 ubiquitin protein ligase |
| Synonyms: | CBLC, CBL-3, CBL3, RNF57, SH3-binding protein CBL-C, SH3-binding protein CBL-3, CBL-c, CBL-SL, RING finger protein 57 |
| Target Sequences: | NM_012116 NP_036248.3 Q9ULV8 |
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