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CASR/Calcium Sensing Receptor
calcium-sensing receptor
CASR, a Calcium-Sensing Receptor, functions as a sensor in parathyroid and kidney to determine extracellular calcium concentration and to maintain calcium homeostasis. This receptor regulates both secretion of parathyroid hormone and excretion of urinary calcium. Mutations that inactivate CASR cause familial hypocalciuric hypercalcemia, which is also correlated with hyperparathyroidism. On the other hand, mutations that activate CASR cause autosomal dominant hypocalcemia. Hjalm et al. (2001) and Awata et al. (2001) have identified the binding of filamin-1 to the C-terminal tail of CASR, which may contribute to its localization in caveolae, link it to the actin-based cytoskeleton, and participate in CASR-mediated activation of MAPK. Multiple isoforms for CASR are produced by alternative splicing.
| Gene Name: | calcium-sensing receptor |
| Family/Subfamily: | GPCR , Calcium-sensing |
| Synonyms: | CASR, Ca sensing receptor, Ca2+ sensing receptor, Calcium-sensing receptor, FIH, EIG8, GPRC2A, HHC, HHC1, Hypocalciuric hypercalcemia 1, PCAR1, NSHPT, CAR, FHH |
| Target Sequences: | NM_000388 NP_000379.2 P41180 |
Publications (3)
1
The Ca2+-sensing receptor activates cytosolic phospholipase A2 via a Gqalpha -dependent ERK-independent pathway. Handlogten ME, Huang C, Shiraishi N, Awata H, Miller RT. The Journal of biological chemistry. 2001 276:13941-8.
[PubMed:11278341]
2
Interaction of the calcium-sensing receptor and filamin, a potential scaffolding protein. Awata H, Huang C, Handlogten ME, Miller RT. The Journal of biological chemistry. 2001 276:34871-9.
[PubMed:11390379]
3
Comparative expression of the extracellular calcium-sensing receptor in the mouse, rat, and human kidney. Graca JA, Schepelmann M, Brennan SC, Reens J, Chang W, Yan P, Toka H, Riccardi D, Price SA. American journal of physiology. Renal physiology. 2016 310:F518-33. (WB; Human)
[Full Text Article]
[PubMed:26661650]
[PMC:PMC5005276]
Related Antibodies: LS-C117834.
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CASR/Calcium Sensing Receptor Mouse anti-Human Monoclonal (N-Terminus) (HL 1499) Antibody
Rabbit, Mouse, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, RIA, WB
Unconjugated
0.1 ml/$460
CASR/Calcium Sensing Receptor Mouse anti-Human Monoclonal (N-Terminus) (Biotin) (HL 1499) Antibody
Rabbit, Mouse, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, RIA, WB
Biotin Conjugated
0.1 ml/$416
CASR/Calcium Sensing Receptor Mouse anti-Human Monoclonal (N-Terminus) (DY650) (HL 1499) Antibody
Rabbit, Mouse, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, RIA, WB
DY650 Conjugated
0.1 ml/$416
CASR/Calcium Sensing Receptor Mouse anti-Human Monoclonal (N-Terminus) (DY488) (HL 1499) Antibody
Rabbit, Mouse, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, RIA, WB
DY488 Conjugated
0.1 ml/$416
CASR/Calcium Sensing Receptor Mouse anti-Human Monoclonal (N-Terminus) (DY550) (HL 1499) Antibody
Rabbit, Mouse, Rat, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, RIA, WB
DY550 Conjugated
0.1 ml/$416
Neuroscience
Fast Shipping
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
Neuroscience
Fast Shipping
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
CASR/Calcium Sensing Receptor Mouse anti-Human Monoclonal (aa214-235) (ADD) Antibody
Chicken, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$460
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal (aa854-903) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
CASR/Calcium Sensing Receptor Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
250 µl/$505
Fast Shipping
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Bovine, Human
IHC, IHC-P
Unconjugated
50 µg/$460
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$832
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µg/$407
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CASR/Calcium Sensing Receptor Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal (pThr888) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal (pThr888) Antibody
Mouse, Rat, Human
ICC, IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal (830-910 aa) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$801
CASR/Calcium Sensing Receptor Rabbit anti-Human Polyclonal (830-910 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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