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BLM

Bloom syndrome, RecQ helicase-like

Participates in DNA replication and repair. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA. Negatively regulates sister chromatid exchange (SCE).

Gene Name: Bloom syndrome, RecQ helicase-like
Synonyms: BLM, Bloom syndrome, Bloom syndrome protein, BS, Bloom's syndrome protein, DNA helicase, RecQ-like type 2, RECQ2, RECQL2, RECQL3, RecQ protein-like 3
Target Sequences: NM_000057 NP_000048.1 P54132

Publications (2)

1
Phosphorylation of BLM, dissociation from topoisomerase IIIalpha, and colocalization with gamma-H2AX after topoisomerase I-induced replication damage. Rao VA, Fan AM, Meng L, Doe CF, North PS, Hickson ID, Pommier Y. Molecular and cellular biology. 2005 25:8925-37. [PubMed:16199871] [PMC:PMC1265790]
2
Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress. Shimura T, Torres MJ, Martin MM, Rao VA, Pommier Y, Katsura M, Miyagawa K, Aladjem MI. Journal of molecular biology. 2008 375:1152-64. [PubMed:18054789] [PMC:PMC2276852]

☰ Filters
Antibodies (29)
Proteins (2)
Primary (29)
Recombinant (2)
BLM (31)
Human (28)
Mouse (5)
Rat (1)
IHC (12)
IHC-P (2)
WB (24)
Flo (7)
ELISA (19)
ICC (1)
IF (8)
IP (4)
Peptide-ELISA (3)
rabbit (26)
mouse (2)
goat (1)
IgG (25)
IgG1 (1)
IgG1,k (1)
monoclonal mc (2)
polyclonal pc (27)
1E4 (1)
BFL 103 (1)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (1)
FITC Conjugated (2)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (23)
aa1054-1082 (7)
pThr99 (3)
40-120 aa (2)
aa1375-C-term (2)
Ab-99 (1)
N-Terminus (1)
aa1-50 (1)
aa100-150 (1)
aa65-114 (1)
pSer1290 (1)
pSer1296 (1)
pSer144 (1)
pSer186 (1)
pSer527 (1)
pThr122 (1)
No (31)
10His, N-terminus + Myc, C-terminus (1)
GST, N-terminus (1)
Human (1)
Mouse (1)
E. coli (1)
Wheat Germ Extract (1)
Purified (1)
Select
BLM Rabbit anti-Human Polyclonal (pSer144) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$567
BLM Antibody - Immunohistochemistry analysis of paraffin-embedded human heart, using Bloom Syndrome (Phospho-Thr99) Antibody. The picture on the right is blocked with the phospho peptide.
Select
BLM Rabbit anti-Human Polyclonal (pThr99) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
BLM Antibody - Immunofluorescence of monoclonal antibody to BLM on HeLa cell . [antibody concentration 10 ug/ml]
Select
BLM Mouse anti-Human Monoclonal (1E4) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$423
Select
BLM Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
BLM Rabbit anti-Human Polyclonal (40-120 aa) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
BLM Antibody - P-peptide - + Immunohistochemistry analysis of paraffin-embedded human heart tissue using Bloom Syndrome Protein (Phospho-Thr99) antibody.
Select
BLM Rabbit anti-Human Polyclonal (pThr99) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
BLM Antibody - Immunohistochemistry analysis of paraffin-embedded human lymph node tissue, using Bloom Syndrome Antibody. The picture on the right is blocked with the synthesized peptide.
Select
BLM Rabbit anti-Human Polyclonal (aa65-114) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
Select
BLM Rabbit anti-Human Polyclonal (40-120 aa) Antibody
Human
ELISA, IF, IHC
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
BLM Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human lymph node tissue using Bloom Syndrome antibody.
Select
BLM Rabbit anti-Human Polyclonal (Ab-99) Antibody
Human
ELISA, IF, IHC
Unconjugated
100 µg/$357
Select
BLM Rabbit anti-Human Polyclonal (pSer1290) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$567
Select
BLM Rabbit anti-Human Polyclonal (pSer527) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$567
Select
BLM Rabbit anti-Human Polyclonal (pSer1296) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$567
Select
BLM Rabbit anti-Human Polyclonal (pThr122) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$567
Select
BLM Rabbit anti-Human Polyclonal (pSer186) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$567
Select
BLM Rabbit anti-Human Polyclonal (aa1054-1082) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
Select
BLM Rabbit anti-Human Polyclonal (aa1054-1082) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
Select
BLM Rabbit anti-Human Polyclonal (aa1054-1082) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
Select
BLM Rabbit anti-Human Polyclonal (aa1054-1082) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
Select
BLM Rabbit anti-Human Polyclonal (aa1054-1082) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
BLM Rabbit anti-Human Polyclonal (aa1054-1082) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
Select
BLM Mouse anti-Human Monoclonal (FITC) (BFL 103) Antibody
Human
ICC, IF
FITC Conjugated
0.05 mg/$634
BLM Antibody - Western blot of BLM Antibody in HL-60 cell line lysates (35 ug/lane). BLM (arrow) was detected using the purified antibody.
Select
BLM Rabbit anti-Human Polyclonal (aa1054-1082) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
Select
BLM Rabbit anti-Human Polyclonal (pThr99) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$567
Select
BLM Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
0.1 mg/$394
Select
BLM Rabbit anti-Human Polyclonal (aa1375-C-term) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
Viewing 1-25 of 31 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).