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ATP1A3
ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP1A3 belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | ATPase, Na+/K+ transporting, alpha 3 polypeptide |
| Family/Subfamily: | Transporter , ATPase - P type, type IIC |
| Synonyms: | ATP1A3, Dystonia 12, DYT12, AHC2, Na+/K+ ATPase 3, Sodium pump subunit alpha-3, RDP |
| Target Sequences: | NM_152296 NP_689509.1 P13637 |
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