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ACTB / Beta Actin

actin, beta

Actin is a highly conserved protein that participates in a wide variety of cellular functions in eukaryotes including muscle contraction, amoeboid movement, cytokinesis and mitotic division. Beta actin is ubiquitously expressed in all eukaryotic cells.

Gene Name:	actin, beta
Synonyms:	ACTB, Actin, cytoplasmic 1, Beta-actin, Beta actin, BRWS1, Actin, beta, Beta cytoskeletal actin, PS1TP5-binding protein 1, PS1TP5BP1
Target Sequences:	NM_001101 NP_001092.1 P60709

Publications (69)

Ceramide enhances cholesterol efflux to apolipoprotein A-I by increasing the cell surface presence of ATP-binding cassette transporter A1. Witting SR, Maiorano JN, Davidson WS. The Journal of biological chemistry. 2003 278:40121-7. (WB; Mouse) [PubMed:12890677]

Oxidant stress leads to impaired regulation of renal cortical oxygen consumption by nitric oxide in the aging kidney. Adler S, Huang H, Wolin MS, Kaminski PM. Journal of the American Society of Nephrology : JASN. 2004 15:52-60. [PubMed:14694157]

Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats. Sun D, Huang A, Yan EH, Wu Z, Yan C, Kaminski PM, Oury TD, Wolin MS, Kaley G. American journal of physiology. Heart and circulatory physiology. 2004 286:H2249-56. [PubMed:14751861]

Genome-wide discovery of loci influencing chemotherapy cytotoxicity. Watters JW, Kraja A, Meucci MA, Province MA, McLeod HL. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:11809-14. [PubMed:15282376] [PMC:PMC511056]

Antiangiogenic and proapoptotic effects of dietary restriction on experimental mouse and human brain tumors. Mukherjee P, Abate LE, Seyfried TN. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004 10:5622-9. [PubMed:15328205]

Oxidant stress in kidneys of spontaneously hypertensive rats involves both oxidase overexpression and loss of extracellular superoxide dismutase. Adler S, Huang H. American journal of physiology. Renal physiology. 2004 287:F907-13. [PubMed:15475543]

GGA proteins mediate the recycling pathway of memapsin 2 (BACE). He X, Li F, Chang WP, Tang J. The Journal of biological chemistry. 2005 280:11696-703. [PubMed:15615712]

A contact-activated kinase signals Candida albicans invasive growth and biofilm development. Kumamoto CA. Proceedings of the National Academy of Sciences of the United States of America. 2005 102:5576-81. [PubMed:15800048] [PMC:PMC556227]

Human T-cell leukemia virus open reading frame II encodes a posttranscriptional repressor that is recruited at the level of transcription. Younis I, Boris-Lawrie K, Green PL. Journal of virology. 2006 80:181-91. [PubMed:16352542] [PMC:PMC1317543]

Bone morphogenetic protein-2 induces proinflammatory endothelial phenotype. Csiszar A, Ahmad M, Smith KE, Labinskyy N, Gao Q, Kaley G, Edwards JG, Wolin MS, Ungvari Z. The American journal of pathology. 2006 168:629-38. [PubMed:16436676] [PMC:PMC1606481]

Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. Ostroukhova M, Qi Z, Oriss TB, Dixon-McCarthy B, Ray P, Ray A. The Journal of clinical investigation. 2006 116:996-1004. [PubMed:16543950] [PMC:PMC1401482]

Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1. Gobeil F, Zhu T, Brault S, Geha A, Vazquez-Tello A, Fortier A, Barbaz D, Checchin D, Hou X, Nader M, Bkaily G, Gratton JP, Heveker N, Ribeiro-da-Silva A, Peri K, Bard H, Chorvatova A, D'Orlans-Juste P, Goetzl EJ, Chemtob S. The Journal of biological chemistry. 2006 281:16058-67. [PubMed:16574649]

Localization and role of NPC1L1 in cholesterol absorption in human intestine. San AT, Sinnett D, Delvin E, Bendayan M, Marcil V, Mnard D, Beaulieu JF, Levy E. Journal of lipid research. 2006 47:2112-20. [PubMed:16829661]

Antioxidant vitamin therapy alters sepsis-related apoptotic myocardial activity and inflammatory responses. Carlson D, Maass DL, White DJ, Tan J, Horton JW. American journal of physiology. Heart and circulatory physiology. 2006 291:H2779-89. [PubMed:16844910]

Interleukin-10 anti-inflammatory response to Borrelia burgdorferi, the agent of Lyme disease: a possible role for suppressors of cytokine signaling 1 and 3. Dennis VA, Jefferson A, Singh SR, Ganapamo F, Philipp MT. Infection and immunity. 2006 74:5780-9. [PubMed:16988256] [PMC:PMC1594918]

Hyperoxic exposure leads to nitrative stress and ensuing microvascular degeneration and diminished brain mass and function in the immature subject. Sirinyan M, Sennlaub F, Dorfman A, Sapieha P, Gobeil F, Hardy P, Lachapelle P, Chemtob S. Stroke; a journal of cerebral circulation. 2006 37:2807-15. [PubMed:17008616]

The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function. Oganesian A, Au S, Horst JA, Holzhausen LC, Macy AJ, Pace JM, Bornstein P. The Journal of biological chemistry. 2006 281:38507-18. [PubMed:17018525] [PMC:PMC3086210]

Adenomatous polyposis coli control of C-terminal binding protein-1 stability regulates expression of intestinal retinol dehydrogenases. Nadauld LD, Phelps R, Moore BC, Eisinger A, Sandoval IT, Chidester S, Peterson PW, Manos EJ, Sklow B, Burt RW, Jones DA. The Journal of biological chemistry. 2006 281:37828-35. [PubMed:17028196]

Vimentin expressed on Mycobacterium tuberculosis-infected human monocytes is involved in binding to the NKp46 receptor. Garg A, Barnes PF, Porgador A, Roy S, Wu S, Nanda JS, Griffith DE, Girard WM, Rawal N, Shetty S, Vankayalapati R. Journal of immunology (Baltimore, Md. : 1950). 2006 177:6192-8. [PubMed:17056548]

Contribution of thioredoxin reductase to T-cell mitogenesis and NF-kappaB DNA-binding promoted by selenite. Ueno H, Kajihara H, Nakamura H, Yodoi J, Nakamuro K. Antioxidants & redox signaling. 2007 9:115-21. [PubMed:17115890]

Lysophosphatidic acid induces endothelial cell death by modulating the redox environment. Brault S, Gobeil F, Fortier A, Honor JC, Joyal JS, Sapieha PS, Kooli A, Martin E, Hardy P, Ribeiro-da-Silva A, Peri K, Lachapelle P, Varma D, Chemtob S. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 292:R1174-83. [PubMed:17122328]

Antenatal antioxidant prevents adult hypertension, vascular dysfunction, and microvascular rarefaction associated with in utero exposure to a low-protein diet. Cambonie G, Comte B, Yzydorczyk C, Ntimbane T, Germain N, L NL, Pladys P, Gauthier C, Lahaie I, Abran D, Lavoie JC, Nuyt AM. American journal of physiology. Regulatory, integrative and comparative physiology. 2007 292:R1236-45. [PubMed:17138729]

Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF. Koivunen P, Hirsil M, Remes AM, Hassinen IE, Kivirikko KI, Myllyharju J. The Journal of biological chemistry. 2007 282:4524-32. [PubMed:17182618]

MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Boutz PL, Chawla G, Stoilov P, Black DL. Genes & development. 2007 21:71-84. [PubMed:17210790] [PMC:PMC1759902]

EHD1 regulates beta1 integrin endosomal transport: effects on focal adhesions, cell spreading and migration. Jovi M, Naslavsky N, Rapaport D, Horowitz M, Caplan S. Journal of cell science. 2007 120:802-14. [PubMed:17284518]

Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like tau and amyloid pathology in mice. Park KH, Hallows JL, Chakrabarty P, Davies P, Vincent I. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 27:2969-78. [PubMed:17360920]

Gap-junctional communication is required for mitotic clonal expansion during adipogenesis. Yanagiya T, Tanabe A, Hotta K. Obesity (Silver Spring, Md.). 2007 15:572-82. [PubMed:17372306] Related Antibodies: LS-B1625.

Apolipoprotein receptor 2 and X11 alpha/beta mediate apolipoprotein E-induced endocytosis of amyloid-beta precursor protein and beta-secretase, leading to amyloid-beta production. He X, Cooley K, Chung CH, Dashti N, Tang J. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 27:4052-60. [PubMed:17428983]

Absence of adenylyl cyclase 3 perturbs peripheral olfactory projections in mice. Zou DJ, Chesler AT, Le Pichon CE, Kuznetsov A, Pei X, Hwang EL, Firestein S. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 27:6675-83. [PubMed:17581954]

IL-21 induces inhibitor of differentiation 2 and leads to complete abrogation of anaphylaxis in mice. Kishida T, Hiromura Y, Shin-Ya M, Asada H, Kuriyama H, Sugai M, Shimizu A, Yokota Y, Hama T, Imanishi J, Hisa Y, Mazda O. Journal of immunology (Baltimore, Md. : 1950). 2007 179:8554-61. [PubMed:18056403] Related Antibodies: LS-B1625.

Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux. Ouimet M, Wang MD, Cadotte N, Ho K, Marcel YL. Arteriosclerosis, thrombosis, and vascular biology. 2008 28:1144-50. (WB) [PubMed:18369155] Related Antibodies: LS-B1625.

Cyclin-dependent kinase-associated proteins Cks1 and Cks2 are essential during early embryogenesis and for cell cycle progression in somatic cells. Martinsson-Ahlzn HS, Liberal V, Grnenfelder B, Chaves SR, Spruck CH, Reed SI. Molecular and cellular biology. 2008 28:5698-709. [PubMed:18625720] [PMC:PMC2546922]

Activated protein C up-regulates IL-10 and inhibits tissue factor in blood monocytes. Toltl LJ, Beaudin S, Liaw PC. Journal of immunology (Baltimore, Md. : 1950). 2008 181:2165-73. [PubMed:18641355] Related Antibodies: LS-B1625.

Fusion of OTT to BSAC results in aberrant up-regulation of transcriptional activity. Sawada T, Nishiyama C, Kishi T, Sasazuki T, Komazawa-Sakon S, Xue X, Piao JH, Ogata H, Nakayama J, Taki T, Hayashi Y, Watanabe M, Yagita H, Okumura K, Nakano H. The Journal of biological chemistry. 2008 283:26820-8. [PubMed:18667423] [PMC:PMC3258922] Related Antibodies: LS-B1625.

UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. Elorza A, Hyde B, Mikkola HK, Collins S, Shirihai OS. The Journal of biological chemistry. 2008 283:30461-70. [PubMed:18687678] [PMC:PMC2576537]

Knockdown of macrophage migration inhibitory factor disrupts adipogenesis in 3T3-L1 cells. Ikeda D, Sakaue S, Kamigaki M, Ohira H, Itoh N, Ohtsuka Y, Tsujino I, Nishimura M. Endocrinology. 2008 149:6037-42. [PubMed:18703634] Related Antibodies: LS-B1625.

Role of aging versus the loss of estrogens in the reduction in vascular function in female rats. Stice JP, Eiserich JP, Knowlton AA. Endocrinology. 2009 150:212-9. [PubMed:18787021] [PMC:PMC2630896]

Tubulobulbar complexes are intercellular podosome-like structures that internalize intact intercellular junctions during epithelial remodeling events in the rat testis. Young JS, Guttman JA, Vaid KS, Vogl AW. Biology of reproduction. 2009 80:162-74. [PubMed:18799754]

The role of lysophosphatidic acid receptor (LPA1) in the oxygen-induced retinal ganglion cell degeneration. Yang C, Lafleur J, Mwaikambo BR, Zhu T, Gagnon C, Chemtob S, Di Polo A, Hardy P. Investigative ophthalmology & visual science. 2009 50:1290-8. [PubMed:18978343]

Regulation of pancreatic tumor cell proliferation and chemoresistance by the histone methyltransferase enhancer of zeste homologue 2. Ougolkov AV, Bilim VN, Billadeau DD. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008 14:6790-6. [PubMed:18980972] [PMC:PMC2690708]

Metal ions-stimulated iron oxidation in hydroxylases facilitates stabilization of HIF-1 alpha protein. Kaczmarek M, Cachau RE, Topol IA, Kasprzak KS, Ghio A, Salnikow K. Toxicological sciences : an official journal of the Society of Toxicology. 2009 107:394-403. [PubMed:19074761] [PMC:PMC2639755]

Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells. Staquicini FI, Dias-Neto E, Li J, Snyder EY, Sidman RL, Pasqualini R, Arap W. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:2903-8. [PubMed:19193855] [PMC:PMC2635839]

Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein. Liu J, Zhang JP, Shi M, Quinn T, Bradner J, Beyer R, Chen S, Zhang J. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009 29:1480-5. [PubMed:19193894] [PMC:PMC3241981]

Curcumin inhibits prosurvival pathways in chronic lymphocytic leukemia B cells and may overcome their stromal protection in combination with EGCG. Ghosh AK, Kay NE, Secreto CR, Shanafelt TD. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:1250-8. [PubMed:19228728]

14-3-3zeta/tau heterodimers regulate Slingshot activity in migrating keratinocytes. Kligys K, Yao J, Yu D, Jones JC. Biochemical and biophysical research communications. 2009 383:450-4. (WB) [PubMed:19371722] [PMC:PMC2727353]

STAT6 activation confers upon T helper cells resistance to suppression by regulatory T cells. Pillemer BB, Qi Z, Melgert B, Oriss TB, Ray P, Ray A. Journal of immunology (Baltimore, Md. : 1950). 2009 183:155-63. [PubMed:19535633] [PMC:PMC2754746]

Calcium-dependent and calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle. Frei E, Huster M, Smital P, Schlossmann J, Hofmann F, Wegener JW. American journal of physiology. Gastrointestinal and liver physiology. 2009 297:G834-9. [PubMed:19628652]

A role for polypyrimidine tract binding protein in the establishment of focal adhesions. Babic I, Sharma S, Black DL. Molecular and cellular biology. 2009 29:5564-77. [PubMed:19667078] [PMC:PMC2756873]

Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1 and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1). Shikama Y, Kuroishi T, Nagai Y, Iwakura Y, Shimauchi H, Takada H, Sugawara S, Endo Y. Innate immunity. 2011 17:15-Mar. [PubMed:19897531] Related Antibodies: LS-B1625.

The pathogen recognition receptor NOD2 regulates human FOXP3+ T cell survival. Rahman MK, Midtling EH, Svingen PA, Xiong Y, Bell MP, Tung J, Smyrk T, Egan LJ, Faubion WA. Journal of immunology (Baltimore, Md. : 1950). 2010 184:7247-56. [PubMed:20483763] Related Antibodies: LS-B1625.

Genetic deletion of the P2Y2 receptor offers significant resistance to development of lithium-induced polyuria accompanied by alterations in PGE2 signaling. Zhang Y, Pop IL, Carlson NG, Kishore BK. American journal of physiology. Renal physiology. 2012 302:F70-7. [PubMed:21975874] Related Antibodies: LS-B1625.

Distribution and subcellular localization of glucocorticoid receptor-immunoreactive neurons in the developing and adult male zebra finch brain. Shahbazi M, Schmidt M, Carruth LL. General and comparative endocrinology. 2011 174:354-61. [PubMed:21986090]

Non-alcoholic fatty liver disease impairs hippocampal-dependent memory in male rats. Ross AP, Bruggeman EC, Kasumu AW, Mielke JG, Parent MB. Physiology & behavior. 2012 106:133-41. (WB; Rat) [PubMed:22280920]

Unexpected gender difference in sensitivity to the acute toxicity of dioxin in mice. Pohjanvirta R, Miettinen H, Sankari S, Hegde N, Lindn J. Toxicology and applied pharmacology. 2012 262:167-76. (WB; Mouse) [PubMed:22564538]

Sexual responses of the male rat medial preoptic area and medial amygdala to estrogen I: site specific suppression of estrogen receptor alpha. Paisley JC, Huddleston GG, Carruth LL, Petrulis A, Grober MS, Clancy AN. Hormones and behavior. 2012 62:50-7. (WB; Rat) [PubMed:22565217]

Pharmacologic stabilization of HIF-1 increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation. Forristal CE, Winkler IG, Nowlan B, Barbier V, Walkinshaw G, Levesque JP. Blood. 2013 121:759-69. [PubMed:23243286]

c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. Piao X, Komazawa-Sakon S, Nishina T, Koike M, Piao JH, Ehlken H, Kurihara H, Hara M, Van Rooijen N, Schtz G, Ohmuraya M, Uchiyama Y, Yagita H, Okumura K, He YW, Nakano H. Science signaling. 2012 5:ra93. [PubMed:23250397] Related Antibodies: LS-B1625.

Acetylation of Lysine 201 Inhibits the DNA-Binding Ability of PhoP to Regulate Salmonella Virulence. Ren J, Sang Y, Tan Y, Tao J, Ni J, Liu S, Fan X, Zhao W, Lu J, Wu W, Yao YF. PLoS pathogens. 2016 12:e1005458. (WB, ELISA; Human, Salmonella typhimurium) [Full Text Article] [PubMed:26943369] [PMC:PMC4778762]

Predictive value of platelet aggregation rate in postpartum deep venous thrombosis and its possible mechanism. Sun M, Liu C, Zhao N, Meng K, Zhang Z. Experimental and therapeutic medicine. 2018 June;15:5215-5220. (Rabbit, Mouse) [Full Text Article] [PubMed:29904405] [PMC:PMC5996703] Related Antibodies: LS-B1625.

URG11 promotes proliferation and induced apoptosis of LNCaP cells. Sun C, Zhang G, Cheng S, Qian H, Li D, Liu M. International journal of molecular medicine. 2019 May;43:2075-2085. [Full Text Article] [PubMed:30864678] [PMC:PMC6443344] Related Antibodies: LS-B1625.

Knockdown of miR-222 inhibits inflammation and the apoptosis of LPS-stimulated human intervertebral disc nucleus pulposus cells. Zhang Y, Yang J, Zhou X, Wang N, Li Z, Zhou Y, Feng J, Shen D, Zhao W. International journal of molecular medicine. 2019 October;44:1357-1365. [Full Text Article] [PubMed:31432092] [PMC:PMC6713428] Related Antibodies: LS-B1625.

Knockdown of KLK12 inhibits viability and induces apoptosis in human colorectal cancer HT-29 cell line. Li Q, Zhou X, Fang Z, Zhou H. International journal of molecular medicine. 2019 November;44:1667-1676. [Full Text Article] [PubMed:31485623] [PMC:PMC6777684] Related Antibodies: LS-B1625.

miR-217 inhibits the migration and invasion of HeLa cells through modulating MAPK1. Zhu L, Yang S, Wang J. International journal of molecular medicine. 2019 November;44:1824-1832. [Full Text Article] [PubMed:31485607] [PMC:PMC6777686] Related Antibodies: LS-B1625.

Effect of estradiol on high glucose-induced osteoblast injury. Li G, Jiang X, Liu L, Liu X, Liu H, Zhang Z. Molecular medicine reports. 2019 October;20:3019-3026. [Full Text Article] [PubMed:31432111] [PMC:PMC6755179] Related Antibodies: LS-B1625.

GOLPH3 Promotes Angiogenesis of Lung Adenocarcinoma by Regulating the Wnt/ß-Catenin Signaling Pathway. Canjun Zhao #, Jin Zhang #, Litian Ma #, Hao Wu, Hui Zhang, Jialin Su, Bizu Geng, Qinghua Yao, Jin Zheng. OncoTargets and therapy. 2020 July;13:6265-6277. [Full Text Article] [PubMed:32636646] [PMC:PMC7335312] Related Antibodies: LS-B1625.

Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models. Chung-Han Hsieh, Li Li, Roeland Vanhauwaert, Kong T Nguyen, Mary D Davis, Guojun Bu, Zbigniew K Wszolek, Xinnan Wang. The Breast : official journal of the European Society of Mastology. 2019 Dec;30:1131-1140.e7. [Full Text Article] [PubMed:31564441] [PMC:PMC6893131] Related Antibodies: LS-C82919.

Recombinant human growth hormone treatment of mice suppresses inflammation and apoptosis caused by skin flap ischemia-reperfusion injury. Ben Liu, Qingjia Xu, Juntao Wang, Junhao Lin, Yantao Pei, Yidong Cui, Gang Wang, Lei Zhu. Journal of cellular biochemistry. 2019 October;120:18162-18171. [Full Text Article] [PubMed:31144385] Related Antibodies: LS-B1625.

Up-regulation of microRNA-574 attenuates lipopolysaccharide- or cecal ligation and puncture-induced sepsis associated with acute lung injury. Wenwen Sun, Hong Li, Jin Gu. Cell biochemistry and function. 2020 October;38:847-858. [Full Text Article] [PubMed:32090367] Related Antibodies: LS-B1625.

The function of long noncoding RNA HOTAIRM1 in the progression of prostate cancer cells. Lei Wang, Longning Wang, Qingfen Wang, Bahman Yosefi, Sen Wei, Xiaodong Wang, Daqing Shen. Andrologia. 2021 March;53:e13897. [Full Text Article] [PubMed:33368390] Related Antibodies: LS-B1625.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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