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ABCB1 / MDR1 / P Glycoprotein
ATP-binding cassette, sub-family B (MDR/TAP), member 1
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
| Gene Name: | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| Family/Subfamily: | Transporter , ATP-binding cassette - ABCB/MDR |
| Synonyms: | ABCB1, ABC20, Abcb1b, CLCS, Colchicin sensitivity, CD243, IBD13, gp170, MDR1, Multidrug resistance protein 1, P glycoprotein, P-glycoprotein 1, P-GP, CD243 antigen, PGY1 |
| Target Sequences: | NM_000927 NP_000918.2 P08183 |
Publications (6)
1
Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia. Kleberg K, Jensen GM, Christensen DP, Lundh M, Grunnet LG, Knuhtsen S, Poulsen SS, Hansen MB, Bindslev N. BMC gastroenterology. 2012 12:78. (IHC; Human)
[Full Text Article]
[PubMed:22734885]
[PMC:PMC3457850]
Related Antibodies: LS-A9403.
2
miR-200c/Bmi1 axis and epithelial-mesenchymal transition contribute to acquired resistance to BRAF inhibitor treatment. Liu S, Tetzlaff MT, Wang T, Yang R, Xie L, Zhang G, Krepler C, Xiao M, Beqiri M, Xu W, Karakousis G, Schuchter L, Amaravadi RK, Xu W, Wei Z, Herlyn M, Yao Y, Zhang L, Wang Y, Zhang L, Xu X. Pigment cell & melanoma research. 2015 28:431-41. (WB; Human)
[Full Text Article]
[PubMed:25903073]
[PMC:PMC4597606]
Related Antibodies: LS-B1448.
3
Chemotherapy-Induced IL8 Upregulates MDR1/ABCB1 in Tumor Blood Vessels and Results in Unfavorable Outcome. Hiroshi Kikuchi, Nako Maishi, Dorcas A Annan, Mohammad Towfik Alam, Randa Ibrahim Hassan Dawood, Masumi Sato, Masahiro Morimoto, Ryo Takeda, Keita Ishizuka, Ryuji Matsumoto, Tomoshige Akino, Kunihiko Tsuchiya, Takashige Abe, Takahiro Osawa, Naoto Miyajima, Satoru Maruyama, Toru Harabayashi, Manabu Azuma, Katsushige Yamashiro, Kaname Ameda, Akira Kashiwagi, Yoshihiro Matsuno, Yasuhiro Hida, Nobuo Shinohara, Kyoko Hida. Cancer research. 2020 July;80:2996-3008. [Full Text Article]
[PubMed:32536602]
Related Antibodies: LS-B1448.
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ABCB1 / MDR1 / P Glycoprotein
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ABCB1 / MDR1 / P Glycoprotein Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
ABCB1 / MDR1 / P Glycoprotein Rabbit anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Human, Monkey
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$515
ABCB1 / MDR1 / P Glycoprotein Mouse anti-Hamster Monoclonal (F4) Antibody
Hamster, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
250 µl/$460
Fast Shipping
ABCB1 / MDR1 / P Glycoprotein Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
ABCB1 / MDR1 / P Glycoprotein Mouse anti-Human Monoclonal (JSB-1) Antibody
Human
Flo, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µl/$460
ABCB1 / MDR1 / P Glycoprotein Mouse anti-Human Monoclonal (UIC2) Antibody
Human
Flo, IF, IHC, IHC-Fr, IHC-P, IP
Unconjugated
0.1 mg/$385
ABCB1 / MDR1 / P Glycoprotein Rabbit anti-Human Polyclonal (aa863-912) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
ABCB1 / MDR1 / P Glycoprotein Mouse anti-Hamster Monoclonal (C219) Antibody
Mouse, Rat, Hamster, Human
Flo, ICC, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
1 ml/$1,134
ABCB1 / MDR1 / P Glycoprotein Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$332
ABCB1 / MDR1 / P Glycoprotein Mouse anti-Human Monoclonal (6H2) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ABCB1 / MDR1 / P Glycoprotein Mouse anti-Human Monoclonal (Magnetic beads) (PG-13) Antibody
Human
IP
Magnetic beads Conjugated
100 µg/$399
Sandwich
96-Well Microplate
Human
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Sandwich
96-Well Strip Plate
Rat
50 - 1000 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
ABCB1 / MDR1 / P Glycoprotein Rabbit anti-Human Polyclonal (aa621-650) Antibody
Mouse, Rat, Chimpanzee, Human
IHC, IHC-Fr, IHC-P
Unconjugated
10 µg/$318; 100 µg/$470
ABCB1 / MDR1 / P Glycoprotein Mouse anti-Hamster-Chinese Monoclonal (JSB-1) Antibody
Hamster-Chinese
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$351
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ABCB1 / MDR1 / P Glycoprotein Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
ABCB1 / MDR1 / P Glycoprotein Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
ABCB1 / MDR1 / P Glycoprotein Mouse anti-Human Monoclonal (3B2) Antibody
Human
IHC
Unconjugated
100 µl/$434
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$798
ABCB1 / MDR1 / P Glycoprotein Mouse anti-Human Monoclonal (OTI2C7) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
ABCB1 / MDR1 / P Glycoprotein Rabbit anti-Human Polyclonal (Ile583) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
50 µl/$321; 100 µl/$403
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product results
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