Osteonectin / SPARC Antibodies

secreted protein, acidic, cysteine-rich (osteonectin)

SPARC (secreted protein acidic and rich in cysteine)/Osteonectin is a matricellular glycoprotein that modulates cellular interactions with the ECM and is expressed in tissues undergoing remodeling. It functions as a de-adhesive protein, as a modulator of growth factor activity, and as a cell-cycle inhibitor. It induces changes in endothelial cell shape via F-actin, coincident with the appearance of intercellular gaps, that provide a paracellular pathway for extravasation of macromolecules. Tumor growth is enhanced in mice lacking SPARC due to changes in the ECM that create a more permissive environment for tumor progression.

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Osteonectin / SPARC Antibodies (19)

Target	Host	Clonality	Format	Epitope	Reactivity	Applications
Osteonectin / SPAR...	Mouse	Monoclonal	Human	ELISA, IHC-P, WB	Osteonectin / SPARC Antibody [1B2] LS-B5537 Mouse Monoclonal (2) 50 µg - 450.00 Applications: IHC-P, WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Mouse	Monoclonal	Bovine, Human, Rat	ELISA, IHC, RIA, WB	Osteonectin / SPARC Antibody LS-C25800 Mouse Monoclonal 100 µg - 325.00 Applications: IHC, WB, ELISA... Epitope:   Reactivity: Bo, Hu, Rt Format: Unconjugated
Osteonectin / SPAR...	Rabbit	Polyclonal	Human	Flo, IHC, WB	Osteonectin / SPARC Antibody LS-C161424 Rabbit Polyclonal (4) 100 µg - 290.00 Applications: IHC, WB, Flo Epitope: aa230-260   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Goat	Polyclonal	Human	Flo, IHC, WB	Osteonectin / SPARC Antibody LS-C150076 Goat Polyclonal (2) 100 µg - 395.00 Applications: IHC, WB, Flo Epitope:   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Goat	Polyclonal	Mouse	Flo, IHC, WB	Osteonectin / SPARC Antibody LS-C150257 Goat Polyclonal (1) 100 µg - 395.00 Applications: IHC, WB, Flo Epitope:   Reactivity: Mu Format: Unconjugated
Osteonectin / SPAR...	Mouse	Monoclonal	Human	IHC-Fr, IHC-P, WB	Osteonectin / SPARC Antibody LS-C83590 Mouse Monoclonal 100 µg - 440.00 Applications: IHC-Fr, IHC-P, WB Epitope:   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Rat	Monoclonal	Mouse	ELISA, Flo, IHC-Fr, IHC-P	Osteonectin / SPARC Antibody LS-C124320 Rat Monoclonal 500 µg - 530.00 Applications: IHC-Fr, IHC-P, Flo... Epitope:   Reactivity: Mu Format: Unconjugated
Osteonectin / SPAR...	Mouse	Monoclonal	Human	Flo, IHC-P, WB	Osteonectin / SPARC Antibody [LM2] LS-C140650 Mouse Monoclonal 100 µg - 330.00 Applications: IHC-P, WB, Flo Epitope:   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Mouse	Monoclonal	Bovine, Human	ELISA, Flo, IHC, WB	Osteonectin / SPARC Antibody LS-C25804 Mouse Monoclonal 100 µg - 480.00 Applications: IHC, WB, Flo... Epitope:   Reactivity: Bo, Hu Format: Unconjugated
Osteonectin / SPAR...	Rabbit	Polyclonal	Human	ELISA, IHC-P	Osteonectin / SPARC Antibody LS-C25802 Rabbit Polyclonal 100 µl - 465.00 Applications: IHC-P, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Rabbit	Polyclonal	Human	ELISA, IHC-P	Osteonectin / SPARC Antibody LS-C122256 Rabbit Polyclonal 20 µl - 350.00 Applications: IHC-P, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Rabbit	Polyclonal	Human	WB	Osteonectin / SPARC Antibody LS-C26929 Rabbit Polyclonal (1) 100 µg - 360.00 Applications: WB Epitope:   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Rabbit	Polyclonal	Human	WB	Osteonectin / SPARC Antibody LS-C145377 Rabbit Polyclonal (1) 50 µg - 380.00 Applications: WB Epitope: C-Terminus   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Mouse	Monoclonal	Human	WB	Osteonectin / SPARC Antibody LS-C156115 Mouse Monoclonal (1) 100 µl - 290.00 Applications: WB Epitope: aa224-251   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Rabbit	Polyclonal	Human	WB	Osteonectin / SPARC Antibody LS-C26933 Rabbit Polyclonal 70 µg - 460.00 Applications: WB Epitope:   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Goat	Polyclonal	Mouse	ELISA, Flo, WB	Osteonectin / SPARC Antibody LS-C131158 Goat Polyclonal 100 µg - 560.00 Applications: WB, Flo, ELISA Epitope:   Reactivity: Mu Format: Unconjugated
Osteonectin / SPAR...	Mouse	Monoclonal	Bovine, Human	ELISA, WB	Osteonectin / SPARC Antibody LS-C25808 Mouse Monoclonal 100 µg - 390.00 Applications: WB, ELISA Epitope:   Reactivity: Bo, Hu Format: Unconjugated
Osteonectin / SPAR...	Rabbit	Polyclonal	Human	ELISA	Osteonectin / SPARC Antibody LS-C124319 Rabbit Polyclonal 20 µl - 350.00 Applications: ELISA Epitope: aa272-286   Reactivity: Hu Format: Unconjugated
Osteonectin / SPAR...	Rabbit	Polyclonal	Human	ELISA	Osteonectin / SPARC Antibody LS-C25805 Rabbit Polyclonal 20 µl - 360.00 Applications: ELISA Epitope: aa272-286   Reactivity: Hu Format: Unconjugated

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Osteonectin / SPARC Feature Table

Feature Type	Location	Details
Function	1 - 303	Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Molecular Weight	1 - 303	34632
Similarity	1 - 303	Belongs to the SPARC family.
Similarity	1 - 303	Contains 1 EF-hand domain.
Similarity	1 - 303	Contains 1 follistatin-like domain.
Similarity	1 - 303	Contains 1 Kazal-like domain.
Subcellular Location	1 - 303	Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane.

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