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AML1 / RUNX1 Antibodies

runt-related transcription factor 1

Gene Name: runt-related transcription factor 1
Synonyms: RUNX1 Antibody, AMLCR1 Antibody, Aml1 oncogene Antibody, AML1 Antibody, AML1-EVI-1 Antibody, CBF-alpha-2 Antibody, CBFA2 Antibody, Acute myeloid leukemia 1 Antibody, EVI-1 Antibody, PEBP2A2 Antibody, PEA2-alpha B Antibody, AML1-EVI-1 fusion protein Antibody, Oncogene AML-1 Antibody, PEBP2-alpha B Antibody, PEBP2aB Antibody
Target Sequences: NM_001754 NP_001745.2 Q01196
 AML1 / RUNX1 Feature Table
Featured Image

Featured AML1 / RUNX1 Antibody

LS-B5383 is a mouse monoclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.

AML1 / RUNX1 Antibodies (34)

Target Host Clonality Format Epitope Reactivity Applications
AML1 / RUNX1 Mouse Monoclonal Human, Mouse ELISA, IF, IHC-P, WB
AML1 / RUNX1 Antibody [4E7] LS-B5383 Mouse Monoclonal thumb(5)
50 µg - 450.00
Applications: IHC-P, IF, WB... Epitope:  
Reactivity: Hu, Mu Format: Unconjugated  
AML1 / RUNX1 Mouse Monoclonal Human ELISA, IF, IHC-P, WB
AML1 / RUNX1 Antibody [2C10] LS-B5384 Mouse Monoclonal thumb(4)
50 µg - 450.00
Applications: IHC-P, IF, WB... Epitope:  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Bovine, Chicken, Dog, Human, Mouse, Rat, Xenopus, Zebrafish IHC-P, WB
AML1 / RUNX1 Antibody LS-B998 Rabbit Polyclonal thumb(3)
50 µg - 385.00
Applications: IHC-P, WB Epitope: N-Terminus  
Reactivity: Bo, Ck, Do ... Format: Unconjugated  
AML1 / RUNX1 Mouse Monoclonal Human ELISA, IF, IHC-P, WB
AML1 / RUNX1 Antibody [3A1] LS-B5382 Mouse Monoclonal thumb(2)
50 µg - 450.00
Applications: IHC-P, IF, WB... Epitope:  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Mouse Monoclonal Human ELISA, IF, IHC-P
AML1 / RUNX1 Antibody [3A8] LS-B5381 Mouse Monoclonal thumb(2)
50 µg - 450.00
Applications: IHC-P, IF, ELISA Epitope:  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Rabbit Monoclonal Human, Mouse Flo, ICC, IHC-P, IP, WB
AML1 / RUNX1 Antibody [EPR3099] LS-C105544 Rabbit Monoclonal thumb(2)
100 µl - 385.00
Applications: IHC-P, ICC, WB... Epitope: C-Terminus  
Reactivity: Hu, Mu Format: Unconjugated  
AML1 / RUNX1 Mouse Monoclonal Human ELISA, ICC, WB
AML1 / RUNX1 Antibody [5A1] LS-C169321 Mouse Monoclonal thumb(4)
100 µl - 350.00
Applications: ICC, WB, ELISA Epitope:  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human Flo, IF, IHC, WB
AML1 / RUNX1 Antibody LS-C162813 Rabbit Polyclonal thumb(4)
100 µg - 290.00
Applications: IHC, IF, WB... Epitope: aa261-290  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human, Mouse, Rat ELISA, IF, IHC-P, WB
AML1 / RUNX1 Antibody LS-C117591 Rabbit Polyclonal thumb(3)
100 µg - 295.00
Applications: IHC-P, IF, WB... Epitope: Internal  
Reactivity: Hu, Mu, Rt Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human, Mouse, Rat IF, IHC, WB
AML1 / RUNX1 Antibody LS-C176260 Rabbit Polyclonal thumb(2)
100 µl - 345.00
Applications: IHC, IF, WB Epitope: His297  
Reactivity: Hu, Mu, Rt Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human, Mouse, Rat IHC, WB
AML1 / RUNX1 Antibody LS-C176580 Rabbit Polyclonal thumb(2)
100 µl - 345.00
Applications: IHC, WB Epitope: Thr270  
Reactivity: Hu, Mu, Rt Format: Unconjugated  
AML1 / RUNX1 Rabbit Monoclonal Human, Mouse IHC-P, WB
AML1 / RUNX1 Antibody [EPR3098] LS-C105734 Rabbit Monoclonal thumb(2)
100 µl - 385.00
Applications: IHC-P, WB Epitope: Internal  
Reactivity: Hu, Mu Format: Unconjugated  
AML1 / RUNX1 Mouse Monoclonal Human ELISA, IHC-P, WB
AML1 / RUNX1 Antibody [4E12] LS-C133014 Mouse Monoclonal thumb(1)
100 µg - 335.00
Applications: IHC-P, WB, ELISA Epitope:  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Mouse Monoclonal Human ELISA, WB
AML1 / RUNX1 Antibody [2B5] LS-C169342 Mouse Monoclonal thumb(3)
100 µl - 350.00
Applications: WB, ELISA Epitope:  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Mouse Monoclonal Human ELISA, IHC, WB
AML1 / RUNX1 Antibody [2B5] LS-C171580 Mouse Monoclonal thumb(2)
100 µl - 365.00
Applications: IHC, WB, ELISA Epitope:  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human, Mouse, Rat ELISA, WB
AML1 / RUNX1 Antibody LS-C118347 Rabbit Polyclonal thumb(1)
100 µg - 295.00
Applications: WB, ELISA Epitope: C-Terminus  
Reactivity: Hu, Mu, Rt Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human, Mouse, Rat ELISA, WB
AML1 / RUNX1 Antibody LS-C108508 Rabbit Polyclonal thumb(1)
100 µg - 325.00
500 µg - 990.00
1000 µg - 1870.00
Applications: WB, ELISA Epitope: Internal  
Reactivity: Hu, Mu, Rt Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Bovine, Chicken, Dog, Human, Mouse, Rat, Xenopus, Zebrafish WB
AML1 / RUNX1 Antibody LS-C110239 Rabbit Polyclonal thumb(1)
50 µg - 370.00
Applications: WB Epitope: Internal  
Reactivity: Bo, Ck, Do ... Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Bovine, Dog, Human, Mouse, Rat, Xenopus WB
AML1 / RUNX1 Antibody LS-C112348 Rabbit Polyclonal thumb(1)
50 µg - 370.00
Applications: WB Epitope: Internal  
Reactivity: Bo, Do, Fr ... Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Bovine, Dog, Human, Mouse, Rat, Xenopus WB
AML1 / RUNX1 Antibody LS-C112355 Rabbit Polyclonal thumb(1)
50 µg - 370.00
Applications: WB Epitope: Internal  
Reactivity: Bo, Do, Fr ... Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Bovine, Chicken, Dog, Human, Mouse, Rat, Xenopus, Zebrafish WB
AML1 / RUNX1 Antibody LS-C112364 Rabbit Polyclonal thumb(1)
50 µg - 370.00
Applications: WB Epitope: Internal  
Reactivity: Bo, Ck, Do ... Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Bovine, Dog, Human, Mouse, Rat WB
AML1 / RUNX1 Antibody LS-C112368 Rabbit Polyclonal thumb(1)
50 µg - 370.00
Applications: WB Epitope: Internal  
Reactivity: Bo, Do, Hu ... Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human WB
AML1 / RUNX1 Antibody LS-C107718 Rabbit Polyclonal thumb(1)
50 µg - 380.00
Applications: WB Epitope: Internal  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human, Mouse WB
AML1 / RUNX1 Antibody LS-C623 Rabbit Polyclonal thumb(1)
100 µg - 265.00
Applications: WB Epitope: aa231-245  
Reactivity: Hu, Mu Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human DB
AML1 / RUNX1 Antibody LS-C163672 Rabbit Polyclonal thumb(1)
100 µg - 290.00
Applications: DB Epitope: aa261-290  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human, Mouse, Rat ELISA, WB
AML1 / RUNX1 Antibody LS-C46862 Rabbit Polyclonal
100 µg - 306.00
Applications: WB, ELISA Epitope: N-Terminus  
Reactivity: Hu, Mu, Rt Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human, Mouse, Rat WB
AML1 / RUNX1 Antibody LS-C94753 Rabbit Polyclonal
500 µg - 343.00
Applications: WB Epitope: Internal  
Reactivity: Hu, Mu, Rt Format: Unconjugated  
AML1 / RUNX1 Sheep Polyclonal Human, Mouse, Rat WB
AML1 / RUNX1 Antibody LS-C94757 Sheep Polyclonal
500 µg - 343.00
Applications: WB Epitope: Internal  
Reactivity: Hu, Mu, Rt Format: Unconjugated  
AML1 / RUNX1 Mouse Monoclonal Human DB
AML1 / RUNX1 Antibody [RUNXA3B6] LS-C184317 Mouse Monoclonal
50 µg - 335.00
Applications: DB Epitope:  
Reactivity: Hu Format:  
AML1 / RUNX1 Rabbit Polyclonal Human ELISA, Flo, IF, IP, WB
AML1 / RUNX1 Antibody LS-C34949 Rabbit Polyclonal
100 µl - 445.00
Applications: IF, WB, Flo... Epitope: pSer249  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human ELISA, WB
AML1 / RUNX1 Antibody LS-C35988 Rabbit Polyclonal
100 µl - 550.00
Applications: WB, ELISA Epitope: C-Terminus  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Rabbit Polyclonal Human, Rodent ELISA, WB
AML1 / RUNX1 Antibody LS-C10038 Rabbit Polyclonal
50 µg - 330.00
Applications: WB, ELISA Epitope: aa240-252  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Mouse Monoclonal Human WB
AML1 / RUNX1 Antibody LS-C75589 Mouse Monoclonal
50 µg - 430.00
Applications: WB Epitope:  
Reactivity: Hu Format: Unconjugated  
AML1 / RUNX1 Rabbit Monoclonal Human Flo
AML1 / RUNX1 Antibody LS-C131970 Rabbit Monoclonal
100 µl - 450.00
Applications: Flo Epitope: C-Terminus  
Reactivity: Hu Format: Unconjugated  

AML1 / RUNX1 Feature Table


Feature Type Location Details
Disease 1 - 453 Defects in RUNX1 are the cause of familial platelet disorder with associated myeloid malignancy (FPDMM) [MIM:601399]. FPDMM is an autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.
Disease 1 - 453 Note=A chromosomal aberration involving RUNX1 is found in acute leukemia. Translocation t(11,21)(q13;q22) that forms a MACROD1-RUNX1 fusion protein.
Disease 1 - 453 Note=A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelogenous leukemia (CML). Translocation t(3;21)(q26;q22) with EAP or MECOM.
Disease 1 - 453 Note=A chromosomal aberration involving RUNX1/AML1 is a cause of chronic myelomonocytic leukemia. Inversion inv(21)(q21;q22) with USP16.
Disease 1 - 453 Note=A chromosomal aberration involving RUNX1/AML1 is a cause of M2 type acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1T1/MTG8/ETO.
Disease 1 - 453 Note=A chromosomal aberration involving RUNX1/AML1 is a cause of therapy-related myelodysplastic syndrome (T-MDS). Translocation t(3;21)(q26;q22) with EAP or MECOM.
Disease 1 - 453 Note=A chromosomal aberration involving RUNX1/AML1 is found in childhood acute lymphoblastic leukemia (ALL). Translocation t(12;21)(p13;q22) with TEL. The translocation fuses the 3'-end of TEL to the alternate 5'-exon of AML-1H.
Disease 1 - 453 Note=A chromosomal aberration involving RUNX1/AML1 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.
Function 1 - 453 CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits MYST4- dependent transcriptional activation.
Modification 14 - 14 Phosphothreonine
Modification 21 - 21 Phosphoserine
Modification 24 - 24 N6-acetyllysine
Modification 43 - 43 N6-acetyllysine
Modification 249 - 249 Phosphoserine
Modification 266 - 266 Phosphoserine
Modification 268 - 268 Phosphoserine
Modification 276 - 276 Phosphoserine
Molecular Weight 1 - 453 48737
Similarity 1 - 453 Contains 1 Runt domain.
Subcellular Location 1 - 453 Nucleus.
Subunit 1 - 453 Heterodimer with CBFB. RUNX1 binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Isoform AML-1L can neither bind DNA nor heterodimerize. Interacts with TLE1 and THOC4. Interacts with ELF1, ELF2 and SPI1. Interacts via its Runt domain with the ELF4 N-terminal region. Interaction with ELF2 isoform 2 (NERF-1a) may act to repress RUNX1-mediated transactivation. Interacts with MYST3 and MYST4. Interacts with SUV39H1, leading to abrogate the transactivating and DNA-binding properties of RUNX1.
Tissue Specificity 1 - 453 Expressed in all tissues examined except brain and heart. Highest levels in thymus, bone marrow and peripheral blood.

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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