RAB7A / RAB7 Antibodies

RAB7A, member RAS oncogene family

RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. RAB7A encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.

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RAB7A / RAB7 Antibodies (7)

Target	Host	Clonality	Format	Epitope	Reactivity	Applications
RAB7A / RAB7	Rabbit	Polyclonal	Bovine, Chicken, Chimpanzee, Dog, Human, Monkey, Rat, Xenopus, Zebrafish	IHC-P, WB	RAB7A / RAB7 Antibody LS-B1789 Rabbit Polyclonal (2) 50 µg - 385.00 Applications: IHC-P, WB Epitope: aa90-140   Reactivity: Bo, Ch, Ck ... Format:
RAB7A / RAB7	Rabbit	Monoclonal	Human, Mouse, Rat	ICC, IHC-P, WB	RAB7A / RAB7 Antibody [EPR7588(B)] LS-B8106 Rabbit Monoclonal (2) 50 µl - 385.00 Applications: IHC-P, ICC, WB Epitope: Internal   Reactivity: Hu, Mu, Rt Format:
RAB7A / RAB7	Rabbit	Polyclonal	Human	Flo, IHC, WB	RAB7A / RAB7 Antibody LS-C162393 Rabbit Polyclonal (3) 100 µg - 290.00 Applications: IHC, WB, Flo Epitope: aa178-207   Reactivity: Hu Format:
RAB7A / RAB7	Rabbit	Polyclonal	Human	IHC, WB	RAB7A / RAB7 Antibody LS-C175838 Rabbit Polyclonal (2) 100 µl - 345.00 Applications: IHC, WB Epitope:   Reactivity: Hu Format:
RAB7A / RAB7	Rabbit	Polyclonal	Bovine, Dog, Human, Mouse, Rat, Sheep	WB	RAB7A / RAB7 Antibody LS-C83876 Rabbit Polyclonal (1) 100 µl - 335.00 Applications: WB Epitope:   Reactivity: Bo, Do, Hu ... Format:
RAB7A / RAB7	Rabbit	Polyclonal	Human, Mouse, Rat	ELISA, WB	RAB7A / RAB7 Antibody LS-C47103 Rabbit Polyclonal 100 µg - 306.00 Applications: WB, ELISA Epitope: N-Terminus   Reactivity: Hu, Mu, Rt Format:
RAB7A / RAB7	Rabbit	Polyclonal	Human, Mouse	WB	RAB7A / RAB7 Antibody LS-C75301 Rabbit Polyclonal 100 µl - 420.00 Applications: WB Epitope: Asp193   Reactivity: Hu, Mu Format:

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RAB7A / RAB7 Feature Table

Feature Type	Location	Details
Disease	1 - 207	Defects in RAB7A are the cause of Charcot-Marie-Tooth disease type 2B (CMT2B) [MIM:600882]; also known as hereditary motor and sensory neuropathy II (HMSN2). CMT2B is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT2 group are characterized by signs of axonal regeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. CMT2B is clinically characterized by marked distal muscle weakness and a high frequency of foot ulcers, infections and amputations of the toes. CMT2B
Function	1 - 207	Involved in late endocytic transport. Contributes to the maturation of phagosomes (acidification).
Modification	72 - 72	Phosphoserine
Modification	183 - 183	Phosphotyrosine
Modification	207 - 207	Cysteine methyl ester (By similarity)
Molecular Weight	1 - 207	23490
Similarity	1 - 207	Belongs to the small GTPase superfamily. Rab family.
Subcellular Location	1 - 207	Late endosome. Lysosome. Cytoplasmic vesicle, phagosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Subunit	1 - 207	Interacts with RILP. Interacts with PSMA7. Interacts with RNF115.
Tissue Specificity	1 - 207	Widely expressed; high expression found in skeletal muscle.

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