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Unfortunately, the antibody LS-C59503 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.


PKM / Pyruvate Kinase Antibodies

PKM / Pyruvate Kinase

This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.

Gene Name: PKM / Pyruvate Kinase
Synonyms: PKM Antibody, p58 Antibody, PK3 Antibody, PKM2 Antibody, Pyruvate Kinase Antibody, Pyruvate kinase 2/3 Antibody, Pyruvate kinase, m1 Antibody, Pyruvate kinase, muscle Antibody, TCB Antibody, Tumor M2-PK Antibody, OIP-3 Antibody, OIP3 Antibody, Opa-interacting protein 3 Antibody, CTHBP Antibody, PK, muscle type Antibody, PK2 Antibody, Pyruvate kinase isozymes M1/M2 Antibody, Pyruvate kinase muscle isozyme Antibody, THBP1 Antibody
Target Sequences: NM_002654 NP_002645.3 P14618
 PKM / Pyruvate Kinase Feature Table
Featured Image

Featured PKM / Pyruvate Kinase Antibody

LS-B1450 is a goat polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.

Publications (2)

1
Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL. Cell. 2011 145:732-44. (WB, ChrIP; Human) [PubMed:21620138] [PMC:PMC3130564]
2
Enhancing mitochondrial respiration suppresses tumor promoter TPA-induced PKM2 expression and cell transformation in skin epidermal JB6 cells. Wittwer JA, Robbins D, Wang F, Codarin S, Shen X, Kevil CG, Huang TT, Van Remmen H, Richardson A, Zhao Y. Cancer prevention research (Philadelphia, Pa.). 2011 4:1476-84. [PubMed:21673231]

PKM / Pyruvate Kinase Antibodies (31)

Target Host Clonality Format Epitope Reactivity Applications
PKM / Pyruvate Kin... Goat Polyclonal Human, Rabbit ELISA, IHC-P, IP, WB
PKM / Pyruvate Kinase Antibody LS-B1450 Goat Polyclonal thumb(1)
50 µl - 385.00
Applications: IHC-P, WB, IP... Epitope:  
Reactivity: Hu, Rb Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human, Monkey, Mouse, Rat IHC-Fr, IHC-P, WB
PKM / Pyruvate Kinase Antibody LS-B2445 Rabbit Polyclonal thumb(1)
50 µl - 385.00
Applications: IHC-Fr, IHC-P, WB Epitope:  
Reactivity: Hu, Mo, Mu ... Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human Flo, IHC, WB
PKM / Pyruvate Kinase Antibody LS-C163750 Rabbit Polyclonal thumb(3)
100 µg - 290.00
Applications: IHC, WB, Flo Epitope: aa123-153  
Reactivity: Hu Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Bovine, Human, Mouse, Rat ICC, IF, IHC-P, WB
PKM / Pyruvate Kinase Antibody LS-C143414 Rabbit Polyclonal thumb(3)
100 µl - 330.00
Applications: IHC-P, ICC, IF... Epitope: aa350-450  
Reactivity: Bo, Hu, Mu ... Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human Flo, IHC, WB
PKM / Pyruvate Kinase Antibody LS-C163751 Rabbit Polyclonal thumb(3)
100 µg - 290.00
Applications: IHC, WB, Flo Epitope: aa393-422  
Reactivity: Hu Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human, Mouse IHC-P, WB
PKM / Pyruvate Kinase Antibody LS-C100685 Rabbit Polyclonal thumb(3)
100 µg - 290.00
Applications: IHC-P, WB Epitope: C-Terminus  
Reactivity: Hu, Mu Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human, Mouse IHC-P, WB
PKM / Pyruvate Kinase Antibody LS-C181996 Rabbit Polyclonal thumb(2)
100 µl - 335.00
Applications: IHC-P, WB Epitope:  
Reactivity: Hu, Mu Format:  
PKM / Pyruvate Kin... Goat Polyclonal Rabbit ELISA, IF, IHC, WB
PKM / Pyruvate Kinase Antibody LS-C59511 Goat Polyclonal
10000 µg - 333.00
Applications: IHC, IF, WB... Epitope:  
Reactivity: Rb Format: Biotin  
PKM / Pyruvate Kin... Sheep Polyclonal Rabbit ELISA, IF, IHC, WB
PKM / Pyruvate Kinase Antibody LS-C147646 Sheep Polyclonal
10000 µg - 195.00
Applications: IHC, IF, WB... Epitope:  
Reactivity: Rb Format:  
PKM / Pyruvate Kin... Sheep Polyclonal Rabbit ELISA, IF, IHC, WB
PKM / Pyruvate Kinase Antibody LS-C147647 Sheep Polyclonal
1000 µl - 330.00
Applications: IHC, IF, WB... Epitope:  
Reactivity: Rb Format: Biotin  
PKM / Pyruvate Kin... Sheep Polyclonal Rabbit ELISA, IF, IHC, WB
PKM / Pyruvate Kinase Antibody LS-C147648 Sheep Polyclonal
1000 µg - 390.00
Applications: IHC, IF, WB... Epitope:  
Reactivity: Rb Format:  
PKM / Pyruvate Kin... Sheep Polyclonal Human, Mouse, Rat ICC, WB
PKM / Pyruvate Kinase Antibody LS-C150140 Sheep Polyclonal thumb(3)
100 µg - 395.00
Applications: ICC, WB Epitope:  
Reactivity: Hu, Mu, Rt Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human, Mouse, Rat WB
PKM / Pyruvate Kinase Antibody LS-C178252 Rabbit Polyclonal thumb(1)
100 µl - 345.00
Applications: WB Epitope: Lys230  
Reactivity: Hu, Mu, Rt Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human WB
PKM / Pyruvate Kinase Antibody LS-C117034 Rabbit Polyclonal thumb(1)
50 µg - 380.00
Applications: WB Epitope: N-Terminus  
Reactivity: Hu Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human WB
PKM / Pyruvate Kinase Antibody LS-C117151 Rabbit Polyclonal thumb(1)
50 µg - 380.00
Applications: WB Epitope: Internal  
Reactivity: Hu Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human, Mouse WB
PKM / Pyruvate Kinase Antibody LS-C98972 Rabbit Polyclonal thumb(1)
100 µg - 290.00
Applications: WB Epitope: N-Terminus  
Reactivity: Hu, Mu Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human, Mouse, Primate, Rat WB
PKM / Pyruvate Kinase Antibody LS-C98973 Rabbit Polyclonal thumb(1)
100 µg - 290.00
Applications: WB Epitope: C-Terminus  
Reactivity: Hu, Mu, Pr ... Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human, Mouse WB
PKM / Pyruvate Kinase Antibody LS-C99052 Rabbit Polyclonal thumb(1)
100 µg - 290.00
Applications: WB Epitope: C-Terminus  
Reactivity: Hu, Mu Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Human WB
PKM / Pyruvate Kinase Antibody LS-C99053 Rabbit Polyclonal thumb(1)
100 µg - 290.00
Applications: WB Epitope: C-Terminus  
Reactivity: Hu Format:  
PKM / Pyruvate Kin... Goat Polyclonal Rabbit ELISA, IP, WB
PKM / Pyruvate Kinase Antibody LS-C59237 Goat Polyclonal
2000 µl - 370.00
Applications: WB, IP, ELISA Epitope:  
Reactivity: Rb Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Bovine, Human, Mouse, Rat ICC, WB
PKM / Pyruvate Kinase Antibody LS-C143415 Rabbit Polyclonal
100 µl - 330.00
Applications: ICC, WB Epitope: aa350-450  
Reactivity: Bo, Hu, Mu ... Format: Biotin  
PKM / Pyruvate Kin... Rabbit Polyclonal Bovine, Human, Mouse, Rat ICC, WB
PKM / Pyruvate Kinase Antibody LS-C143416 Rabbit Polyclonal
100 µl - 330.00
Applications: ICC, WB Epitope: aa350-450  
Reactivity: Bo, Hu, Mu ... Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Bovine, Human, Mouse, Rat ICC, WB
PKM / Pyruvate Kinase Antibody LS-C143417 Rabbit Polyclonal
100 µl - 330.00
Applications: ICC, WB Epitope: aa350-450  
Reactivity: Bo, Hu, Mu ... Format:  
PKM / Pyruvate Kin... Rabbit Polyclonal Bovine, Human, Mouse, Rat ICC, WB
PKM / Pyruvate Kinase Antibody LS-C143418 Rabbit Polyclonal
100 µl - 330.00
Applications: ICC, WB Epitope: aa350-450  
Reactivity: Bo, Hu, Mu ... Format: HRP  
PKM / Pyruvate Kin... Rabbit Polyclonal Bovine, Human, Mouse, Rat ICC, WB
PKM / Pyruvate Kinase Antibody LS-C143419 Rabbit Polyclonal
100 µl - 330.00
Applications: ICC, WB Epitope: aa350-450  
Reactivity: Bo, Hu, Mu ... Format:  
PKM / Pyruvate Kin... Mouse Monoclonal Human
PKM / Pyruvate Kinase Antibody LS-C113047 Mouse Monoclonal
50 µl - 225.00
Applications: Epitope:  
Reactivity: Hu Format:  
PKM / Pyruvate Kin... Goat Polyclonal Rabbit
PKM / Pyruvate Kinase Antibody LS-C86196 Goat Polyclonal
50000 µg - 500.00
Applications: Epitope:  
Reactivity: Rb Format:  
PKM / Pyruvate Kin... Goat Polyclonal Rabbit ELISA, IF, IP, WB
PKM / Pyruvate Kinase Antibody LS-C38680 Goat Polyclonal
1000 µg - 230.00
Applications: IF, WB, IP... Epitope:  
Reactivity: Rb Format: Biotin  
PKM / Pyruvate Kin... Goat Polyclonal Rabbit ELISA, IP, WB
PKM / Pyruvate Kinase Antibody LS-C38678 Goat Polyclonal
1000 µl - 280.00
Applications: WB, IP, ELISA Epitope:  
Reactivity: Rb Format:  
PKM / Pyruvate Kin... Mouse Monoclonal Human ELISA, IF, WB
PKM / Pyruvate Kinase Antibody LS-C131760 Mouse Monoclonal
100 µl - 425.00
Applications: IF, WB, ELISA Epitope: aa1-531  
Reactivity: Hu Format:  
PKM / Pyruvate Kin... Sheep Polyclonal Human ELISA
PKM / Pyruvate Kinase Antibody LS-C93516 Sheep Polyclonal
1000 µl - 530.00
Applications: ELISA Epitope:  
Reactivity: Hu Format:  

PKM / Pyruvate Kinase Feature Table


Feature Type Location Details
Function 1 - 531 Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.
Modification 2 - 2 N-acetylserine
Modification 37 - 37 Phosphoserine
Modification 45 - 45 Phosphothreonine
Modification 62 - 62 N6-acetyllysine
Modification 83 - 83 Phosphotyrosine
Modification 89 - 89 N6-acetyllysine
Modification 105 - 105 Phosphotyrosine
Modification 148 - 148 Phosphotyrosine
Modification 166 - 166 N6-acetyllysine
Modification 175 - 175 Phosphotyrosine
Modification 195 - 195 Phosphothreonine
Modification 266 - 266 N6-acetyllysine
Modification 328 - 328 Phosphothreonine
Modification 390 - 390 Phosphotyrosine
Modification 433 - 433 N6-acetyllysine
Molecular Weight 1 - 531 57937
pathway 1 - 531 Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 5/5.
Similarity 1 - 531 Belongs to the pyruvate kinase family.
Subcellular Location 1 - 531 Cytoplasm. Nucleus. Note=Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic actvity.
Subunit 1 - 531 Monomer and homotetramer. Exists as a monomer in the absence of FBP, and reversibly associates to form a homotetramer in the presence of FBP. The monomeric form binds T3. Tetramer formation induces pyruvate kinase activity. The tetrameric form has high affinity for the substrate and is associated within the glycolytic enzyme complex. Exists in a nearly inactive dimeric form in tumor cells and the dimeric form has less affinity for the substrate. Binding to certain oncoproteins such as HPV-16 E7 oncoprotein can trigger dimerization. FBP stimulates the formation of tetramers from dimers. Interacts with HERC1, POU5F1 and PML.
Tissue Specificity 1 - 531 Specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, as well as cancer cells.

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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