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The Immunohistochemistry Antibody Company
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PDI / P4HB Antibodies
prolyl 4-hydroxylase, beta polypeptide
P4HB encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex.
| Gene Name: | prolyl 4-hydroxylase, beta polypeptide |
| Synonyms: | P4HB Antibody, ERBA2L Antibody, DSI Antibody, GIT Antibody, p4HB Antibody, p4Hbeta Antibody, PDIA1 Antibody, PHDB Antibody, PO4DB Antibody, PROHB Antibody, Protocollagen hydroxylase Antibody, Protein disulfide-isomerase Antibody, PO4HB Antibody, PDI Antibody |
| Target Sequences: | NM_000918 NP_000909.2 P07237 |
| PDI / P4HB Feature Table |
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Featured PDI / P4HB AntibodyLS-B2162 is a mouse monoclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed. |
PDI / P4HB Antibodies (11)
| Target | Host | Clonality | Format | Epitope | Reactivity | Applications | |||||||||||
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| PDI / P4HB | Mouse | Monoclonal | Human | ELISA, IHC-Fr, IHC-P, WB |
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| PDI / P4HB | Mouse | Monoclonal | Bovine, Chicken, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Xenopus | ICC, IHC-P, WB |
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| PDI / P4HB | Mouse | Monoclonal | Hamster, Human, Mouse, Pig, Rat | Flo, Func, ICC, IHC-Fr, IHC-P, IP, WB |
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| PDI / P4HB | Rabbit | Polyclonal | Human | ICC, IF, IHC-P, WB |
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| PDI / P4HB | Rabbit | Polyclonal | Human | ICC, IHC-P, WB |
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| PDI / P4HB | Rabbit | Polyclonal | Human | Flo, IHC, WB |
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| PDI / P4HB | Rabbit | Polyclonal | Bovine, Chicken, Human, Mouse, Rabbit, Rat, Xenopus | IHC, WB |
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| PDI / P4HB | Mouse | Monoclonal | Human, Rat | IF, IHC-Fr, IHC-P, IP, WB |
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| PDI / P4HB | Mouse | Monoclonal | Rat | IHC-P |
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| PDI / P4HB | Rabbit | Polyclonal | Bovine, Chicken, Human, Mouse, Rabbit, Rat, Xenopus | WB |
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| PDI / P4HB | Rabbit | Polyclonal | Bovine, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rat, Sheep, Xenopus | WB |
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PDI / P4HB Feature Table
| Feature Type | Location | Details |
|---|---|---|
| Function | 1 - 508 | This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. |
| Molecular Weight | 1 - 508 | 57116 |
| Similarity | 1 - 508 | Belongs to the protein disulfide isomerase family. |
| Similarity | 1 - 508 | Contains 2 thioredoxin domains. |
| Subcellular Location | 1 - 508 | Endoplasmic reticulum lumen. Melanosome. Cell membrane; Peripheral membrane protein (Potential). Note=Highly abundant. In some cell types, seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources (Probable). Localizes near CD4-enriched regions on lymphoid cell surfaces. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Subunit | 1 - 508 | Homodimer. Monomers and homotetramers may also occur. Also constitutes the structural subunit of prolyl 4-hydroxylase and of the microsomal triacylglycerol transfer protein MTTP in mammalian cells. Stabilizes both enzymes and retain them in the ER without contributing to the catalytic activity (By similarity). Binds UBQLN1. Binds to CD4, and upon HIV-1 binding to the cell membrane, is part of a P4HB/PDI-CD4-CXCR4-gp120 complex. |
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