PDCD4 Antibodies

programmed cell death 4 (neoplastic transformation inhibitor)

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified. PDCD4 inhibits the translation initiation factor E1F4A. Phosphorylation by AKT causes nuclear translocation of PDCD4 and also decreases the ability of PDCD4 to interfere with the transactivation of AP-1 responsive promoter by c-JUN. Loss of PDCD4 expression in human lung carcinoma correlates with tumor progression and prognosis.

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PDCD4 Antibodies (22)

Target	Host	Clonality	Format	Epitope	Reactivity	Applications
PDCD4	Mouse	Monoclonal	Human	ELISA, IHC-P, WB	PDCD4 Antibody [K4C1] LS-B2949 Mouse Monoclonal (4) 50 µg - 385.00 Applications: IHC-P, WB, ELISA Epitope: aa1-469   Reactivity: Hu Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human, Mouse, Rat, Xenopus	ELISA, IHC-P, WB	PDCD4 Antibody LS-B65 Rabbit Polyclonal (3) 50 µg - 385.00 Applications: IHC-P, WB, ELISA Epitope: C-Terminus   Reactivity: Fr, Hu, Mu ... Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human, Mouse, Rat, Xenopus	ELISA, IHC-P, WB	PDCD4 Antibody LS-B487 Rabbit Polyclonal (2) 50 µg - 385.00 Applications: IHC-P, WB, ELISA Epitope: pSer457   Reactivity: Fr, Hu, Mu ... Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human, Mouse, Rat	IHC-P, WB	PDCD4 Antibody LS-B6949 Rabbit Polyclonal (2) 100 µl - 385.00 Applications: IHC-P, WB Epitope:   Reactivity: Hu, Mu, Rt Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human, Mouse, Rat	IHC-P, WB	PDCD4 Antibody LS-B1388 Rabbit Polyclonal (1) 50 µg - 385.00 Applications: IHC-P, WB Epitope: C-Terminus   Reactivity: Hu, Mu, Rt Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human	ICC, IHC-P, IP, WB	PDCD4 Antibody LS-C179904 Rabbit Polyclonal (5) 100 µl - 335.00 Applications: IHC-P, ICC, WB... Epitope:   Reactivity: Hu Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human, Mouse	IHC-P, WB	PDCD4 Antibody LS-C179905 Rabbit Polyclonal (3) 100 µl - 335.00 Applications: IHC-P, WB Epitope:   Reactivity: Hu, Mu Format: Unconjugated
PDCD4	Mouse	Monoclonal	Human, Mouse, Rat, Xenopus	ELISA, IHC, WB	PDCD4 Antibody [9G6] LS-C154004 Mouse Monoclonal (3) 100 µg - 380.00 Applications: IHC, WB, ELISA Epitope: pSer457   Reactivity: Fr, Hu, Mu ... Format: Unconjugated
PDCD4	Rabbit	Monoclonal	Human	Flo, ICC, IHC-P, IP, WB	PDCD4 Antibody [EPR3431] LS-C105569 Rabbit Monoclonal (2) 100 µl - 415.00 Applications: IHC-P, ICC, WB... Epitope: N-Terminus   Reactivity: Hu Format: Unconjugated
PDCD4	Rabbit	Monoclonal	Human, Mouse	Flo, ICC, IHC-P, WB	PDCD4 Antibody [EPR3432] LS-C105556 Rabbit Monoclonal (2) 100 µl - 415.00 Applications: IHC-P, ICC, WB... Epitope: C-Terminus   Reactivity: Hu, Mu Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human, Mouse, Rat	IF, IHC, WB	PDCD4 Antibody LS-C176644 Rabbit Polyclonal (2) 100 µl - 345.00 Applications: IHC, IF, WB Epitope: Lys453   Reactivity: Hu, Mu, Rt Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human	IHC, WB	PDCD4 Antibody LS-C163460 Rabbit Polyclonal (2) 100 µg - 290.00 Applications: IHC, WB Epitope: aa120-149   Reactivity: Hu Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human	ELISA, IHC-P, WB	PDCD4 Antibody LS-C122296 Rabbit Polyclonal 50 µg - 435.00 Applications: IHC-P, WB, ELISA Epitope: C-Terminus   Reactivity: Hu Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human, Mouse, Rat	ELISA, IF, WB	PDCD4 Antibody LS-C118014 Rabbit Polyclonal (2) 100 µg - 295.00 Applications: IF, WB, ELISA Epitope: C-Terminus   Reactivity: Hu, Mu, Rt Format: Unconjugated
PDCD4	Mouse	Monoclonal	Human, Mouse, Rat, Xenopus	ELISA, IP, WB	PDCD4 Antibody [9G6] LS-C153791 Mouse Monoclonal (1) 50 µg - 325.00 Applications: WB, IP, ELISA Epitope: pSer457   Reactivity: Fr, Hu, Mu ... Format: Biotin
PDCD4	Goat	Polyclonal	Bovine, Dog, Human, Mouse, Porcine, Rat	ELISA, WB	PDCD4 Antibody LS-C155028 Goat Polyclonal (1) 100 µg - 360.00 Applications: WB, ELISA Epitope: Internal   Reactivity: Bo, Do, Hu ... Format: Unconjugated
PDCD4	Goat	Polyclonal	Bovine, Dog, Human, Mouse, Porcine, Rat	ELISA, WB	PDCD4 Antibody LS-C155029 Goat Polyclonal (1) 100 µg - 360.00 Applications: WB, ELISA Epitope: aa210-221   Reactivity: Bo, Do, Hu ... Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Bovine, Dog, Human, Mouse, Rat	WB	PDCD4 Antibody LS-C29959 Rabbit Polyclonal (1) 50 µg - 380.00 Applications: WB Epitope: N-Terminus   Reactivity: Bo, Do, Hu ... Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human	WB	PDCD4 Antibody LS-C31656 Rabbit Polyclonal (1) 100 µg - 335.00 Applications: WB Epitope: N-Terminus   Reactivity: Hu Format: Unconjugated
PDCD4	Mouse	Monoclonal	Human	ELISA, WB	PDCD4 Antibody LS-C74212 Mouse Monoclonal 50 µl - 365.00 Applications: WB, ELISA Epitope: aa1-469   Reactivity: Hu Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human	IP, WB	PDCD4 Antibody LS-C93128 Rabbit Polyclonal 100 µg - 535.00 Applications: WB, IP Epitope: aa419-469   Reactivity: Hu Format: Unconjugated
PDCD4	Rabbit	Polyclonal	Human	IP	PDCD4 Antibody LS-C93127 Rabbit Polyclonal 100 µg - 535.00 Applications: IP Epitope: aa100-150   Reactivity: Hu Format: Unconjugated

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PDCD4 Feature Table

Feature Type	Location	Details
Function	1 - 469	Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Inhibits the helicase activity of EIF4A and cap-dependent translation. Binds RNA (By similarity).
Induction	1 - 469	IL2 stimulation inhibits expression, while IL12 increases expression.
Modification	76 - 76	Phosphoserine
Modification	78 - 78	Phosphoserine
Modification	80 - 80	Phosphoserine
Modification	93 - 93	Phosphothreonine
Modification	94 - 94	Phosphoserine
Modification	152 - 152	Phosphotyrosine
Modification	457 - 457	Phosphoserine
Molecular Weight	1 - 469	51721
Similarity	1 - 469	Belongs to the PDCD4 family.
Similarity	1 - 469	Contains 2 MI domains.
Subcellular Location	1 - 469	Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions. Exported from the nucleus in the absence of serum.
Subunit	1 - 469	Interacts with EIF4A1 and EIF4A2 (By similarity).
Tissue Specificity	1 - 469	Up-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma.

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