Unfortunately, the antibody LS-C52473 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.

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LOX-1 Antibodies

oxidized low density lipoprotein (lectin-like) receptor 1

LOX-1 (OLR1) encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. The gene is regulated through the cyclic AMP signaling pathway. LOX-1 binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.

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LOX-1 Antibodies (17)

Target	Host	Clonality	Format	Epitope	Reactivity	Applications
LOX-1	Rabbit	Polyclonal	Human, Mouse, Rat	IHC-P, WB	LOX-1 Antibody LS-B2202 Rabbit Polyclonal (2) 50 µg - 385.00 Applications: IHC-P, WB Epitope: N-Terminus   Reactivity: Hu, Mu, Rt Format: Unconjugated
LOX-1	Rabbit	Polyclonal	Human	IHC, WB	LOX-1 Antibody LS-C163119 Rabbit Polyclonal (3) 100 µg - 290.00 Applications: IHC, WB Epitope: aa71-100   Reactivity: Hu Format: Unconjugated
LOX-1	Sheep	Polyclonal	Human	Flo, IHC-Fr, IP, WB	LOX-1 Antibody LS-C43121 Sheep Polyclonal (1) 50 µg - 345.00 Applications: IHC-Fr, WB, Flo... Epitope: Extracellular Domain   Reactivity: Hu Format: Unconjugated
LOX-1	Sheep	Polyclonal	Human	Flo, IHC-Fr, IP, WB	LOX-1 Antibody LS-C123992 Sheep Polyclonal 50 µg - 465.00 Applications: IHC-Fr, WB, Flo... Epitope: Extracellular Domain   Reactivity: Hu Format: Unconjugated
LOX-1	Rabbit	Polyclonal	Human	WB	LOX-1 Antibody LS-C80709 Rabbit Polyclonal (1) 100 µg - 335.00 Applications: WB Epitope: N-Terminus   Reactivity: Hu Format: Unconjugated
LOX-1	Rabbit	Polyclonal	Human	WB	LOX-1 Antibody LS-C155737 Rabbit Polyclonal (1) 100 µl - 335.00 Applications: WB Epitope:   Reactivity: Hu Format: Unconjugated
LOX-1	Mouse	Monoclonal	Human	Flo, Func, IF	LOX-1 Antibody [23C11] LS-C140059 Mouse Monoclonal 100 µg - 520.00 Applications: IF, Flo, Func Epitope: Extracellular Domain   Reactivity: Hu Format: Unconjugated
LOX-1	Mouse	Monoclonal	Human	Flo, Func, IF	LOX-1 Antibody [23C11] LS-C140060 Mouse Monoclonal 50 µg - 395.00 Applications: IF, Flo, Func Epitope: Extracellular Domain   Reactivity: Hu Format: Biotin
LOX-1	Mouse	Monoclonal	Human	Flo, Func, IF	LOX-1 Antibody [23C11] LS-C140061 Mouse Monoclonal 100 µg - 560.00 Applications: IF, Flo, Func Epitope: Extracellular Domain   Reactivity: Hu Format: FITC
LOX-1	Mouse	Monoclonal	Human	ELISA, WB	LOX-1 Antibody [LOX20-15] LS-C52474 Mouse Monoclonal 200 µg - 408.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
LOX-1	Mouse	Monoclonal	Human	ELISA, WB	LOX-1 Antibody [LOX20-20] LS-C52475 Mouse Monoclonal 200 µg - 408.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
LOX-1	Mouse	Monoclonal	Human	ELISA, WB	LOX-1 Antibody [LOX19-22] LS-C58301 Mouse Monoclonal 200 µg - 335.00 Applications: WB, ELISA Epitope: aa58-273   Reactivity: Hu Format: Unconjugated
LOX-1	Mouse	Monoclonal	Human	ELISA, WB	LOX-1 Antibody [LOX20-7] LS-C58302 Mouse Monoclonal 200 µg - 335.00 Applications: WB, ELISA Epitope: aa58-273   Reactivity: Hu Format: Unconjugated
LOX-1	Mouse	Monoclonal	Human	Flo, Neut	LOX-1 Antibody LS-C125883 Mouse Monoclonal 100 µg - 585.00 Applications: Flo, Neut Epitope:   Reactivity: Hu Format: Unconjugated
LOX-1	Rabbit	Polyclonal	Human	ELISA, IF	LOX-1 Antibody LS-C130512 Rabbit Polyclonal 100 µl - 450.00 Applications: IF, ELISA Epitope: C-Terminus   Reactivity: Hu Format: Unconjugated
LOX-1	Rabbit	Polyclonal	Human	ELISA, IF	LOX-1 Antibody LS-C130513 Rabbit Polyclonal 100 µl - 450.00 Applications: IF, ELISA Epitope: N-Terminus   Reactivity: Hu Format: Unconjugated
LOX-1	Rat	Monoclonal	Mouse	ELISA	LOX-1 Antibody LS-C125886 Rat Monoclonal 500 µg - 530.00 Applications: ELISA Epitope: aa60-363   Reactivity: Mu Format: Unconjugated

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LOX-1 Feature Table

Feature Type	Location	Details
Disease	1 - 273	Defects in OLR1 may be a cause of susceptibility to myocardial infarction [MIM:608557].
Disease	1 - 273	Defects in OLR1 may be associated with susceptibility to Alzheimer disease (AD) [MIM:104300]. Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not.
Function	1 - 273	Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocy
Induction	1 - 273	By inflammatory cytokines such as TNF-alpha, IFN-gamma, IL-6 and by pathological conditions such as hyperlipidemia, hypertension and diabetes mellitus. Up-regulated in atherosclerotic lesions, by oxLDL, reactive oxygen species and fluid shear stress, suggesting that it may participate in amplification of oxLDL-induced vascular dysfunction.
Molecular Weight	1 - 273	30959
Similarity	1 - 273	Contains 1 C-type lectin domain.
Subcellular Location	1 - 273	Cell membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form also exists.
Subunit	1 - 273	Homodimer; disulfide-linked. May form a hexamer composed of 3 homodimers. Interacts with HSP70.
Tissue Specificity	1 - 273	Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.

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