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GDF5 / GDF-5 Antibodies

growth differentiation factor 5

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development.

Gene Name: growth differentiation factor 5
Family/Subfamily: TGF beta
Synonyms: GDF5 Antibody, CDMP-1 Antibody, CDMP1 Antibody, GDF-5 Antibody, LAP4 Antibody, Radotermin Antibody, OS5 Antibody, BMP14 Antibody, SYNS2 Antibody
Target Sequences: NM_000557 NP_000548.1 P43026
 GDF5 / GDF-5 Feature Table
Featured Image

Featured GDF5 / GDF-5 Antibody

LS-B808 is a rabbit polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.


GDF5 / GDF-5 Antibodies (28)

Target Reactivity Applications Host Isotype Clonality Clone Format Epitope Publications Type
GDF5 / GDF-5 Rabbit Polyclonal Unconjugated Human IHC-P, ELISA aa28-41 No Primary
Anti-GDF5 / GDF-5 Antibody (aa28-41) IHC-plus™ LS-B808
IHC Image
Rabbit Polyclonal to Human GDF5 / GDF-5
Human
IHC - Paraffin, ELISA
Unconjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal Unconjugated Human IHC-P, WB No Primary
Anti-GDF5 / GDF-5 Antibody IHC-plus™ LS-B8753
IHC Image
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC - Paraffin, Western blot
Unconjugated
GDF5 / GDF-5 Rabbit Polyclonal Unconjugated Human, Chimpanzee, Orangutan, Gibbon, Monkey, Rabbit, Chicken WB aa372-421 No Primary
Anti-GDF5 / GDF-5 Antibody (aa372-421) LS-C169734
WB Image
Rabbit Polyclonal to Human GDF5 / GDF-5
Human, Chimpanzee, Orangutan, Gibbon, Monkey, Rabbit, Chicken
Western blot
Unconjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal Unconjugated Human WB, ELISA No Primary
Anti-GDF5 / GDF-5 Antibody LS-C35177
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
Western blot, ELISA
Unconjugated
GDF5 / GDF-5 Rabbit Polyclonal Unconjugated Human IHC-P, WB aa350-379 No Primary
Anti-GDF5 / GDF-5 Antibody (aa350-379) LS-C166428
IHC Image
WB Image
Rabbit Polyclonal to Human GDF5 / GDF-5
Human
IHC - Paraffin, Western blot
Unconjugated
GDF5 / GDF-5 Rabbit Polyclonal Unconjugated Human IHC-P, WB N-Terminus No Primary
Anti-GDF5 / GDF-5 Antibody (N-Terminus) LS-C97995
IHC Image
WB Image
Rabbit Polyclonal to Human GDF5 / GDF-5
Human
IHC - Paraffin, Western blot
Unconjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal Unconjugated Human IHC-P, IHC-Fr, ICC, IF, WB, ELISA aa382-501 No
Anti-GDF5 / GDF-5 Antibody (aa382-501) LS-C302246
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC - Paraffin, IHC - Frozen, ICC, Immunofluorescence, Western blot, ELISA
Unconjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal Unconjugated Human IHC-P, IHC-Fr, ICC, WB, ELISA aa382-501 No
Anti-GDF5 / GDF-5 Antibody (aa382-501) LS-C298134
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
Unconjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal Unconjugated Mouse IHC-P, IHC-Fr, ICC, WB, ELISA aa358-495 No
Anti-GDF5 / GDF-5 Antibody (aa358-495) LS-C300455
Rabbit Polyclonal (IgG) to Mouse GDF5 / GDF-5
Mouse
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
Unconjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal Unconjugated Human IHC-P, IHC-Fr, ICC, WB, ELISA aa382-501 No
Anti-GDF5 / GDF-5 Antibody (aa382-501) LS-C294353
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
Unconjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal Unconjugated Mouse IHC-P, IHC-Fr, ICC, WB, ELISA aa358-495 No
Anti-GDF5 / GDF-5 Antibody (aa358-495) LS-C294357
Rabbit Polyclonal (IgG) to Mouse GDF5 / GDF-5
Mouse
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
Unconjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal Unconjugated Mouse IHC, ICC, IF, WB aa358-495 No
Anti-GDF5 / GDF-5 Antibody (aa358-495) LS-C305258
Rabbit Polyclonal (IgG) to Mouse GDF5 / GDF-5
Mouse
IHC, ICC, Immunofluorescence, Western blot
Unconjugated
GDF5 / GDF-5 Goat IgG Polyclonal Unconjugated Mouse IHC-Fr, WB, ELISA No Primary
Anti-GDF5 / GDF-5 Antibody LS-C150200
Goat Polyclonal (IgG) to Mouse GDF5 / GDF-5
Mouse
IHC - Frozen, Western blot, ELISA
Unconjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal FITC Conjugated Human IHC, WB, ELISA N-Terminus No Primary
Anti-GDF5 / GDF-5 Antibody (N-Terminus, FITC) LS-C244566
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
FITC Conjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal APC Conjugated Human IHC, WB, ELISA N-Terminus No Primary
Anti-GDF5 / GDF-5 Antibody (N-Terminus, APC) LS-C244565
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
APC Conjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal Biotin Conjugated Human IHC, WB, ELISA N-Terminus No Primary
Anti-GDF5 / GDF-5 Antibody (N-Terminus, Biotin) LS-C244564
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
Biotin Conjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human IHC, WB, ELISA aa350-379 No Primary
Anti-GDF5 / GDF-5 Antibody (aa350-379, Azide-free, HRP) LS-C249053
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
HRP Conjugated, Azide-free
GDF5 / GDF-5 Rabbit IgG Polyclonal HRP Conjugated, Azide-free Human IHC, WB, ELISA N-Terminus No Primary
Anti-GDF5 / GDF-5 Antibody (N-Terminus, Azide-free, HRP) LS-C247614
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
HRP Conjugated, Azide-free
GDF5 / GDF-5 Rabbit IgG Polyclonal PE Conjugated Human IHC, WB, ELISA N-Terminus No Primary
Anti-GDF5 / GDF-5 Antibody (N-Terminus, PE) LS-C244567
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
PE Conjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal Biotin Conjugated Human IHC, WB, ELISA aa350-379 No Primary
Anti-GDF5 / GDF-5 Antibody (aa350-379, Biotin) LS-C235605
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
Biotin Conjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal APC Conjugated Human IHC, WB, ELISA aa350-379 No Primary
Anti-GDF5 / GDF-5 Antibody (aa350-379, APC) LS-C235604
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
APC Conjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal AP Conjugated Human IHC, WB, ELISA aa350-379 No Primary
Anti-GDF5 / GDF-5 Antibody (aa350-379, AP) LS-C235603
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
AP Conjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal AP Conjugated Human IHC, WB, ELISA N-Terminus No Primary
Anti-GDF5 / GDF-5 Antibody (N-Terminus, AP) LS-C244563
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
AP Conjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal PE Conjugated Human IHC, WB, ELISA aa350-379 No Primary
Anti-GDF5 / GDF-5 Antibody (aa350-379, PE) LS-C235609
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
PE Conjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal FITC Conjugated Human IHC, WB, ELISA aa350-379 No Primary
Anti-GDF5 / GDF-5 Antibody (aa350-379, FITC) LS-C235606
Rabbit Polyclonal (IgG) to Human GDF5 / GDF-5
Human
IHC, Western blot, ELISA
FITC Conjugated
GDF5 / GDF-5 Chicken IgY Polyclonal Unconjugated Human WB, ELISA No Primary
Anti-GDF5 / GDF-5 Antibody LS-C149147
Chicken Polyclonal (IgY) to Human GDF5 / GDF-5
Human
Western blot, ELISA
Unconjugated
GDF5 / GDF-5 Rabbit IgG Polyclonal Unconjugated Mouse WB, ELISA No Primary
Anti-GDF5 / GDF-5 Antibody LS-C285510
Rabbit Polyclonal (IgG) to Mouse GDF5 / GDF-5
Mouse
Western blot, ELISA
Unconjugated
GDF5 / GDF-5 Rat IgG2b Monoclonal Unconjugated Mouse ELISA, Func, Neut No Primary
Anti-GDF5 / GDF-5 Antibody LS-C36583
Rat Monoclonal (IgG2b) to Mouse GDF5 / GDF-5
Mouse
ELISA, Functional Assay, Neutralization
Unconjugated

GDF5 / GDF-5 Feature Table


Feature Type Location Details
Disease 1 - 501 Defects in GDF5 are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits.
Disease 1 - 501 Defects in GDF5 are a cause of symphalangism proximal syndrome (SYM1) [MIM:185800]. SYM1 is characterized by the hereditary absence of the proximal interphalangeal (PIP) joints (Cushing symphalangism). Severity of PIP joint involvement diminishes towards the radial side. Distal interphalangeal joints are less frequently involved and metacarpophalangeal joints are rarely affected whereas carpal bone malformation and fusion are common. In the lower extremities, tarsal bone coalition is common. Conducive hearing loss is seen and is due to fusion of the stapes to the petrous part of the temporal bone.
Disease 1 - 501 Defects in GDF5 are the cause of acromesomelic chondrodysplasia Grebe type (AMDG) [MIM:200700]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDG is an autosomal recessive form characterized by normal axial skeletons and missing or fused skeletal elements within the hands and feet.
Disease 1 - 501 Defects in GDF5 are the cause of acromesomelic chondrodysplasia Hunter-Thompson type (AMDH) [MIM:201250]. AMDH is an autosomal recessive form of dwarfism. Patients have limb abnormalities, with the middle and distal segments being most affected and the lower limbs more affected than the upper. AMDH is characterized by normal axial skeletons and missing or fused skeletal elements within the hands and feet.
Disease 1 - 501 Defects in GDF5 are the cause of brachydactyly type C (BDC) [MIM:113100]. BDC is an autosomal dominant disorder characterized by an abnormal shortness of the fingers and toes.
Disease 1 - 501 Defects in GDF5 are the cause of Du Pan syndrome [MIM:228900]; also known as fibular hypoplasia and complex brachydactyly. Du Pan syndrome is a rare autosomal recessive condition characterized by absence of the fibulae and severe acromesomelic limb shortening with small, non-functional toes. Although milder, the phenotype resembles the autosomal recessive Hunter-Thompson [MIM:201250] and Grebe types [MIM:200700] of acromesomelic chondrodysplasia.
Disease 1 - 501 Defects in GDF5 are the cause of multiple synostoses syndrome type 2 (SYNS2) [MIM:610017]. Multiple synostoses syndrome is an autosomal dominant condition characterized by progressive joint fusions of the fingers, wrists, ankles and cervical spine, characteristic facies and progressive conductive deafness.
Disease 1 - 501 Genetic variations in GDF5 are associated with susceptibility to osteoarthritis type 5 (OS5) [MIM:612400]. Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement.
Function 1 - 501 Could be involved in bone formation.
Similarity 1 - 501 Belongs to the TGF-beta family.
Subcellular Location 1 - 501 Secreted.
Subunit 1 - 501 Homodimer; disulfide-linked (By similarity).
Tissue Specificity 1 - 501 Predominantly expressed in long bones during embryonic development.
web resource 1 - 501 Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/GDF5";
web resource 1 - 501 Name=Wikipedia; Note=GDF5 entry; URL="http://en.wikipedia.org/wiki/GDF5";
arrayexpress 1 - 501 P43026
bgee 1 - 501 P43026
cleanex 1 - 501 HS_GDF5
ctd 1 - 501 8200
dip 1 - 501 DIP-5823N
doi 1 - 501 10
eggnog 1 - 501 prNOG11414
embl 1 - 501 AL121586
embl 1 - 501 BC032495
embl 1 - 501 U13660
embl 1 - 501 X80915
ensembl 1 - 501 ENST00000374369
ensembl 1 - 501 ENST00000374372
genecards 1 - 501 GC20M034021
geneid 1 - 501 8200
genevestigator 1 - 501 P43026
germonline 1 - 501 ENSG00000125965
go 1 - 501 GO:0005125
go 1 - 501 GO:0005615
go 1 - 501 GO:0007179
go 1 - 501 GO:0007267
go 1 - 501 GO:0008083
go 1 - 501 GO:0040007
h-invdb 1 - 501 HIX0040743
hgnc 1 - 501 HGNC:4220
hogenom 1 - 501 HBG717159
hovergen 1 - 501 HBG107938
hpa 1 - 501 HPA015648
inparanoid 1 - 501 P43026
interpro 1 - 501 IPR001111
interpro 1 - 501 IPR001839
interpro 1 - 501 IPR015615
interpro 1 - 501 IPR017948
ipi 1 - 501 IPI00015522
kegg 1 - 501 hsa:8200
medline 1 - 501 21638749
medline 1 - 501 22117167
medline 1 - 501 95050604
medline 1 - 501 95071375
medline 1 - 501 97434212
mim 1 - 501 112600
mim 1 - 501 113100
mim 1 - 501 185800
mim 1 - 501 200700
mim 1 - 501 201250
mim 1 - 501 228900
mim 1 - 501 601146
mim 1 - 501 610017
mim 1 - 501 612400
nextbio 1 - 501 30902
oma 1 - 501 PITPHEY
orphanet 1 - 501 2098
orphanet 1 - 501 2639
orphanet 1 - 501 3237
orphanet 1 - 501 3250
orphanet 1 - 501 69028
orphanet 1 - 501 93384
orphanet 1 - 501 93396
orphanet 1 - 501 968
orthodb 1 - 501 EOG9HDWDD
panther 1 - 501 PTHR11848
pdb 1 - 501 1WAQ
pdb 1 - 501 2BHK
pdb 1 - 501 3EVS
pdbsum 1 - 501 1WAQ
pdbsum 1 - 501 2BHK
pdbsum 1 - 501 3EVS
pfam 1 - 501 PF00019
pfam 1 - 501 PF00688
pharmgkb 1 - 501 PA28635
phylomedb 1 - 501 P43026
pir 1 - 501 A55452
pir 1 - 501 JC2347
pride 1 - 501 P43026
prosite 1 - 501 PS00250
prosite 1 - 501 PS51362
proteinmodelportal 1 - 501 P43026
pubmed 1 - 501 11780052
pubmed 1 - 501 12121354
pubmed 1 - 501 14735582
pubmed 1 - 501 15489334
pubmed 1 - 501 16127465
pubmed 1 - 501 16222676
pubmed 1 - 501 16532400
pubmed 1 - 501 16892395
pubmed 1 - 501 17384641
pubmed 1 - 501 18203755
pubmed 1 - 501 18283415
pubmed 1 - 501 18629880
pubmed 1 - 501 7961761
pubmed 1 - 501 7980526
pubmed 1 - 501 9288098
refseq 1 - 501 NP_000548.1
smart 1 - 501 SM00204
string 1 - 501 P43026
ucsc 1 - 501 uc002xck.1
unigene 1 - 501 Hs.1573
carbohyd 189 - 189 N-linked (GlcNAc...) (Potential)
chain 382 - 501 Growth/differentiation factor 5 /FTId=PRO_0000033913.
conflict 38 - 38 T -> S (in Ref. 2; AAA57007)
conflict 254 - 258 APGGG -> VPRSR (in Ref. 2; AAA57007)
conflict 321 - 321 A -> T (in Ref. 2; AAA57007)
conflict 384 - 384 L -> S (in Ref. 2; AAA57007)
disulfid 400 - 466 By similarity
disulfid 429 - 498 By similarity
disulfid 433 - 500 By similarity
disulfid 465 - 465 Interchain (By similarity)
propep 28 - 381 Potential /FTId=PRO_0000033912.
signal 1 - 27 Potential
variant 163 - 163 R -> G (in dbSNP:rs34534075) /FTId=VAR_037977.
variant 173 - 173 M -> V (in BDC; dbSNP:rs28936397) /FTId=VAR_037978.
variant 276 - 276 S -> A (in dbSNP:rs224331) /FTId=VAR_026120.
variant 373 - 373 L -> R (in SYM1; the mature GDF5 protein is detected as the wild-type in the supernatant derived from the mutant transfected cells). /FTId=VAR_054909.
variant 378 - 378 R -> Q (in Du Pan syndrome) /FTId=VAR_054910.
variant 380 - 380 R -> Q (in BDA2; reduces activity; impairs processing). /FTId=VAR_046743.
variant 400 - 400 C -> Y (in AMDG) /FTId=VAR_017407.
variant 436 - 436 P -> T (in Du Pan syndrome) /FTId=VAR_054911.
variant 437 - 437 Missing (in Du Pan syndrome; located on the same allele as T-439 and L-440). /FTId=VAR_037979.
variant 438 - 438 R -> L (in SYNS2 and SYM1; increased biologic activity when compared to wild- type; normal binding to BMPR1B ectodomain but increased binding to that of BMPR1A). /FTId=VAR_026545.
variant 439 - 439 S -> T (in Du Pan syndrome; located on the same allele as L-437 del and L-440). /FTId=VAR_037980.
variant 440 - 440 H -> L (in Du Pan syndrome; located on the same allele as L-437 del and T-439). /FTId=VAR_037981.
variant 441 - 441 L -> P (in Du Pan syndrome and BDA2; the mutant is almost inactive; loss of binding to BMPR1A and BMPR1B ectodomains; dbSNP:rs28936683). /FTId=VAR_017408.
variant 475 - 475 S -> N (in SYNS2) /FTId=VAR_037982.
variant 491 - 491 E -> K (in SYM1) /FTId=VAR_037983.
keyword 1 - 501 3D-structure
keyword 1 - 501 Cleavage on pair of basic residues
keyword 1 - 501 Complete proteome
keyword 1 - 501 Cytokine
keyword 1 - 501 Disease mutation
keyword 1 - 501 Disulfide bond
keyword 1 - 501 Dwarfism
keyword 1 - 501 Glycoprotein
keyword 1 - 501 Growth factor
keyword 1 - 501 Polymorphism
keyword 1 - 501 Secreted
keyword 1 - 501 Signal
Molecular Weight 1 - 501 55411
1 hit 1 - 501 PF00019
1 hit 1 - 501 PF00688
1 hit 1 - 501 PS00250
1 hit 1 - 501 PS51362

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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