EPHA2 Antibodies

EPH receptor A2

EPH receptor A2 (EPHA2) belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. EPHA2 binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.

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EPHA2 Antibodies (23)

Target	Host	Clonality	Format	Epitope	Reactivity	Applications
EPHA2	Mouse	Monoclonal	Human	ELISA, IHC-P, WB	EPHA2 Antibody [1B3C7] LS-B3903 Mouse Monoclonal (3) 50 µl - 385.00 Applications: IHC-P, WB, ELISA Epitope:   Reactivity: Hu Format:
EPHA2	Mouse	Monoclonal	Human, Mouse	ELISA, IHC-P, WB	EPHA2 Antibody [3D7] LS-B3002 Mouse Monoclonal (3) 50 µg - 385.00 Applications: IHC-P, WB, ELISA Epitope: aa559-976   Reactivity: Hu, Mu Format:
EPHA2	Rabbit	Polyclonal	Bovine, Chimpanzee, Dog, Horse, Human, Monkey, Mouse, Rat	IHC-P, WB	EPHA2 Antibody LS-B1794 Rabbit Polyclonal (2) 50 µg - 385.00 Applications: IHC-P, WB Epitope: aa450-500   Reactivity: Bo, Ch, Do ... Format:
EPHA2	Mouse	Monoclonal	Bovine, Dog, Human, Mouse	Flo, ICC, WB	EPHA2 Antibody LS-C36249 Mouse Monoclonal 100 µg - 445.00 Applications: ICC, WB, Flo Epitope: Extracellular Domain   Reactivity: Bo, Do, Hu ... Format:
EPHA2	Rabbit	Polyclonal	Hamster, Human, Mouse	Flo, IHC-P, WB	EPHA2 Antibody LS-C100255 Rabbit Polyclonal (5) 100 µg - 290.00 Applications: IHC-P, WB, Flo Epitope: N-Terminus   Reactivity: Ha, Hu, Mu Format:
EPHA2	Mouse	Monoclonal	Human	ELISA, IHC, WB	EPHA2 Antibody [1B3C7] LS-C171363 Mouse Monoclonal (2) 100 µl - 345.00 Applications: IHC, WB, ELISA Epitope:   Reactivity: Hu Format:
EPHA2	Rabbit	Polyclonal	Human	DB, WB	EPHA2 Antibody LS-C163608 Rabbit Polyclonal (2) 100 µg - 290.00 Applications: WB, DB Epitope: pS897   Reactivity: Hu Format:
EPHA2	Rabbit	Polyclonal	Human, Rat	IF, WB	EPHA2 Antibody LS-C176508 Rabbit Polyclonal (1) 100 µl - 345.00 Applications: IF, WB Epitope: Thr587/595   Reactivity: Hu, Rt Format:
EPHA2	Rabbit	Polyclonal	Human, Mouse	WB	EPHA2 Antibody LS-C178069 Rabbit Polyclonal (1) 100 µl - 345.00 Applications: WB Epitope: pTyr588   Reactivity: Hu, Mu Format:
EPHA2	Rabbit	Polyclonal	Mouse	WB	EPHA2 Antibody LS-C164374 Rabbit Polyclonal (1) 100 µg - 290.00 Applications: WB Epitope: aa295-323   Reactivity: Mu Format:
EPHA2	Rabbit	Polyclonal	Hamster, Human, Mouse	WB	EPHA2 Antibody LS-C100256 Rabbit Polyclonal (1) 100 µg - 290.00 Applications: WB Epitope: C-Terminus   Reactivity: Ha, Hu, Mu Format:
EPHA2	Rabbit	Monoclonal	Human	WB	EPHA2 Antibody [EPR4761] LS-C138399 Rabbit Monoclonal (1) 100 µl - 385.00 Applications: WB Epitope: C-Terminus   Reactivity: Hu Format:
EPHA2	Rabbit	Monoclonal	Human	WB	EPHA2 Antibody [EP4760] LS-C138653 Rabbit Monoclonal (1) 100 µl - 385.00 Applications: WB Epitope: Extracellular Domain   Reactivity: Hu Format:
EPHA2	Mouse	Monoclonal	Bovine, Dog, Human, Mouse, Rat	Func, ICC, IP, WB	EPHA2 Antibody LS-C6535 Mouse Monoclonal 200 µg - 530.00 Applications: ICC, WB, IP... Epitope:   Reactivity: Bo, Do, Hu ... Format:
EPHA2	Mouse	Monoclonal	Human, Mouse, Rat	ELISA, IP, WB	EPHA2 Antibody LS-C6537 Mouse Monoclonal 100 µg - 490.00 Applications: WB, IP, ELISA Epitope: C-Terminus   Reactivity: Hu, Mu, Rt Format:
EPHA2	Mouse	Monoclonal	Dog, Human, Mouse, Rat	ELISA, IP, WB	EPHA2 Antibody LS-C9218 Mouse Monoclonal 100 µl - 540.00 Applications: WB, IP, ELISA Epitope:   Reactivity: Do, Hu, Mu ... Format:
EPHA2	Mouse	Monoclonal	Human	ELISA, Flo, IF	EPHA2 Antibody [GM5H5] LS-C90394 Mouse Monoclonal 50 µg - 470.00 Applications: IF, Flo, ELISA Epitope:   Reactivity: Hu Format:
EPHA2	Rabbit	Polyclonal	Human	IP, WB	EPHA2 Antibody LS-C6536 Rabbit Polyclonal 100 µg - 500.00 Applications: WB, IP Epitope: C-Terminus   Reactivity: Hu Format:
EPHA2	Mouse	Monoclonal	Human	ELISA, WB	EPHA2 Antibody LS-C125527 Mouse Monoclonal 100 µl - 395.00 Applications: WB, ELISA Epitope: aa559-976   Reactivity: Hu Format:
EPHA2	Rat	Monoclonal	Mouse	WB	EPHA2 Antibody LS-C125528 Rat Monoclonal 100 µg - 550.00 Applications: WB Epitope: Extracellular Domain   Reactivity: Mu Format:
EPHA2	Mouse	Monoclonal	Human	Flo	EPHA2 Antibody [D7] LS-C128748 Mouse Monoclonal 100 tst - 435.00 Applications: Flo Epitope:   Reactivity: Hu Format: PE
EPHA2	Rat	Monoclonal	Mouse	Flo	EPHA2 Antibody LS-C36250 Rat Monoclonal 100 tst - 585.00 Applications: Flo Epitope:   Reactivity: Mu Format: APC
EPHA2	Rat	Monoclonal	Mouse	Flo	EPHA2 Antibody LS-C36251 Rat Monoclonal 100 tst - 510.00 Applications: Flo Epitope:   Reactivity: Mu Format: PE

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EPHA2 Feature Table

Feature Type	Location	Details
Disease	1 - 976	Defects in EPHA2 are the cause of cataract posterior polar type 1 (CTPP1) [MIM:116600]. A subcapsular opacity, usually disk-shaped, located at the back of the lens. It can have a marked effect on visual acuity.
Disease	1 - 976	Genetic variations in EPHA2 are the cause of susceptibility to cataract cortical age-related type 2 (ARCC2) [MIM:613020]. A developmental punctate opacity common in the cortex and present in most lenses. The cataract is white or cerulean, increases in number with age, but rarely affects vision.
Function	1 - 976	Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 and -A5. Plays an important role in angiogenesis and tumor neovascularization. The recruitement of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity). Induces apoptosis in a TP53/p53-independent, caspase-8-dependent manner.
Induction	1 - 976	By ultraviolet radiation (UV) via a TP53/p53- independent, but MAPK-dependent, mechanism.
Modification	153 - 153	Phosphoserine
Modification	373 - 373	Phosphoserine
Modification	570 - 570	Phosphoserine
Modification	575 - 575	Phosphotyrosine
Modification	579 - 579	Phosphoserine
Modification	587 - 587	Phosphothreonine
Modification	588 - 588	Phosphotyrosine; by autocatalysis (By similarity).
Modification	593 - 593	Phosphothreonine
Modification	594 - 594	Phosphotyrosine; by autocatalysis
Modification	628 - 628	Phosphotyrosine
Modification	647 - 647	Phosphothreonine
Modification	735 - 735	Phosphotyrosine; by autocatalysis (By similarity).
Modification	771 - 771	Phosphothreonine
Modification	772 - 772	Phosphotyrosine; by autocatalysis
Modification	790 - 790	Phosphoserine
Modification	791 - 791	Phosphotyrosine
Modification	869 - 869	Phosphoserine
Modification	880 - 880	Phosphoserine
Modification	892 - 892	Phosphoserine
Modification	897 - 897	Phosphoserine
Modification	898 - 898	Phosphothreonine
Modification	899 - 899	Phosphoserine
Modification	901 - 901	Phosphoserine
Modification	910 - 910	Phosphoserine
Modification	921 - 921	Phosphotyrosine; by autocatalysis (Potential).
Modification	930 - 930	Phosphotyrosine
Modification	960 - 960	Phosphotyrosine
Molecular Weight	1 - 976	108266
Similarity	1 - 976	Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.
Similarity	1 - 976	Contains 1 protein kinase domain.
Similarity	1 - 976	Contains 1 SAM (sterile alpha motif) domain.
Similarity	1 - 976	Contains 2 fibronectin type-III domains.
Subcellular Location	1 - 976	Membrane; Single-pass type I membrane protein.
Subunit	1 - 976	Monomer at low protein concentrations (around 10 uM) and forms homodimers at higher concentrations. Forms heterodimers with EFNA1. Interacts with SLA. The phosphorylated form interacts with VAV2, VAV3 and PI3-kinase p85 subunit (By similarity). Interacts with INPPL1/SHIP2.
Tissue Specificity	1 - 976	Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g., skin, intestine, lung, and ovary.

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