DKK1 Antibodies

dickkopf homolog 1 (Xenopus laevis)

Dickkopf Homolog 1 (DKK1) is a member of the Dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma.

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DKK1 Antibodies (22)

Target	Host	Clonality	Format	Epitope	Reactivity	Applications
DKK1	Rabbit	Polyclonal	Human	IHC-P	DKK1 Antibody LS-A2867 Rabbit Polyclonal (1) 50 µg - 385.00 Applications: IHC-P Epitope: Cytoplasmic Domain   Reactivity: Hu Format: Unconjugated
DKK1	Rabbit	Polyclonal	Human	IHC-P	DKK1 Antibody LS-A2866 Rabbit Polyclonal (1) 50 µg - 385.00 Applications: IHC-P Epitope: N-Terminus   Reactivity: Hu Format: Unconjugated
DKK1	Rabbit	Polyclonal	Human	IHC-P	DKK1 Antibody LS-A2865 Rabbit Polyclonal (1) 50 µg - 385.00 Applications: IHC-P Epitope: N-Terminus   Reactivity: Hu Format: Unconjugated
DKK1	Rabbit	Polyclonal	Human	IHC-P	DKK1 Antibody LS-A2868 Rabbit Polyclonal (1) 50 µg - 385.00 Applications: IHC-P Epitope: Internal   Reactivity: Hu Format: Unconjugated
DKK1	Goat	Polyclonal	Human	ELISA, IHC-P, WB	DKK1 Antibody LS-B194 Goat Polyclonal (1) 50 µg - 385.00 Applications: IHC-P, WB, ELISA Epitope: C-Terminus   Reactivity: Hu Format: Unconjugated
DKK1	Rabbit	Monoclonal	Human, Rat	Flo, ICC, IHC-P, WB	DKK1 Antibody [EPR4759] LS-B8698 Rabbit Monoclonal (3) 50 µl - 385.00 Applications: IHC-P, ICC, WB... Epitope:   Reactivity: Hu, Rt Format: Unconjugated
DKK1	Rabbit	Polyclonal	Human, Mouse, Rabbit	WB	DKK1 Antibody LS-C47394 Rabbit Polyclonal (1) 100 µg - 330.00 Applications: WB Epitope: aa150-200   Reactivity: Hu, Mu, Rb Format: Unconjugated
DKK1	Goat	Polyclonal	Mouse	ELISA, IHC, WB	DKK1 Antibody LS-C150180 Goat Polyclonal (1) 100 µg - 395.00 Applications: IHC, WB, ELISA Epitope:   Reactivity: Mu Format: Unconjugated
DKK1	Rat	Monoclonal	Mouse	IHC, WB	DKK1 Antibody [259631] LS-C150181 Rat Monoclonal (1) 100 µg - 320.00 Applications: IHC, WB Epitope:   Reactivity: Mu Format: Unconjugated
DKK1	Mouse	Monoclonal	Human	ELISA, WB	DKK1 Antibody [2A5] LS-C105117 Mouse Monoclonal (2) 100 µg - 335.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
DKK1	Rabbit	Polyclonal	Human	IHC-P	DKK1 Antibody LS-C121732 Rabbit Polyclonal 50 µg - 590.00 Applications: IHC-P Epitope:   Reactivity: Hu Format: Unconjugated
DKK1	Mouse	Monoclonal	Human	ELISA, WB	DKK1 Antibody [2B12] LS-C105116 Mouse Monoclonal (1) 100 µg - 335.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
DKK1	Mouse	Monoclonal	Human	ELISA, WB	DKK1 Antibody [2H2] LS-C108793 Mouse Monoclonal (1) 100 µl - 290.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
DKK1	Mouse	Monoclonal	Human	ELISA, WB	DKK1 Antibody [2H2] LS-C171450 Mouse Monoclonal (1) 100 µl - 315.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
DKK1	Rabbit	Polyclonal	Human	WB	DKK1 Antibody LS-C167428 Rabbit Polyclonal (1) 100 µg - 290.00 Applications: WB Epitope: aa64-93   Reactivity: Hu Format: Unconjugated
DKK1	Rabbit	Polyclonal	Human, Mouse, Rat	WB	DKK1 Antibody LS-C146990 Rabbit Polyclonal (1) 100 µg - 385.00 Applications: WB Epitope:   Reactivity: Hu, Mu, Rt Format: Unconjugated
DKK1	Rabbit	Polyclonal	Bovine, Chicken, Dog, Human, Mouse, Pig, Rabbit, Rat, Xenopus, Zebrafish	WB	DKK1 Antibody LS-C81144 Rabbit Polyclonal (1) 100 µg - 335.00 Applications: WB Epitope: C-Terminus   Reactivity: Bo, Ck, Do ... Format: Unconjugated
DKK1	Rabbit	Polyclonal	Bovine, Chimpanzee, Horse, Human, Monkey, Mouse, Rat	ELISA	DKK1 Antibody LS-C47458 Rabbit Polyclonal 100 µl - 325.00 Applications: ELISA Epitope:   Reactivity: Bo, Ch, Ho ... Format: Unconjugated
DKK1	Rabbit	Polyclonal	Human	ELISA	DKK1 Antibody LS-C3385 Rabbit Polyclonal 100 µg - 245.00 Applications: ELISA Epitope: aa45-73   Reactivity: Hu Format: Unconjugated
DKK1	Sheep	Polyclonal	Rat	ELISA, WB	DKK1 Antibody LS-C64746 Sheep Polyclonal 100 µg - 590.00 Applications: WB, ELISA Epitope:   Reactivity: Rt Format: Unconjugated
DKK1	Rabbit	Polyclonal	Human, Mouse	WB	DKK1 Antibody LS-C6401 Rabbit Polyclonal 50 µg - 317.00 Applications: WB Epitope: C-Terminus   Reactivity: Hu, Mu Format: Unconjugated
DKK1	Rabbit	Polyclonal	Human	WB	DKK1 Antibody LS-C64738 Rabbit Polyclonal 100 µl - 420.00 Applications: WB Epitope: Gln75   Reactivity: Hu Format: Unconjugated

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DKK1 Feature Table

Feature Type	Location	Details
Function	1 - 266	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease.
Molecular Weight	1 - 266	28672
Similarity	1 - 266	Belongs to the dickkopf family.
Subcellular Location	1 - 266	Secreted.
Subunit	1 - 266	Interacts with LRP6. Interacts (via the C-termianl Cys- rich domain) with LRP5 (via beta-propeller regions 3 and 4); the interaction, enhanced by MESD and or KREMEN, antagonizes Wnt- mediated signaling.
Tissue Specificity	1 - 266	Placenta.

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