Unfortunately, the antibody LS-C13318 is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.

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CD41 Antibodies

integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)

Integrin, Alpha 2B (CD41B/ITGA2B) encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibronectin receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

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CD41 Antibodies (95)

Target	Host	Clonality	Format	Epitope	Reactivity	Applications
CD41	Mouse	Monoclonal	Bovine, Human	Flo, IHC-P	CD41 Antibody LS-B8762 Mouse Monoclonal (1) 50 µg - 385.00 Applications: IHC-P, Flo Epitope:   Reactivity: Bo, Hu Format: FITC
CD41	Rabbit	Polyclonal	Human, Mouse	ELISA, IHC, WB	CD41 Antibody LS-C153279 Rabbit Polyclonal 100 µg - 365.00 Applications: IHC, WB, ELISA Epitope: N-Terminus   Reactivity: Hu, Mu Format: Unconjugated
CD41	Rabbit	Monoclonal	Human	IHC-P, WB	CD41 Antibody [EPR4330] LS-C138517 Rabbit Monoclonal (2) 100 µl - 385.00 Applications: IHC-P, WB Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Rat	Monoclonal	Mouse	Flo, IHC-Fr, IP	CD41 Antibody LS-C13281 Rat Monoclonal 250 µg - 425.00 Applications: IHC-Fr, Flo, IP Epitope:   Reactivity: Mu Format: Unconjugated
CD41	Mouse	Monoclonal	Baboon, Human, Mink	Flo	CD41 Antibody LS-C45123 Mouse Monoclonal 100 tst - 320.00 Applications: Flo Epitope:   Reactivity: Ba, Hu, Mi Format: RPE
CD41	Rabbit	Polyclonal	Human	WB	CD41 Antibody LS-C144712 Rabbit Polyclonal 100 µl - 355.00 Applications: WB Epitope: N-Terminus   Reactivity: Hu Format: Unconjugated
CD41	Rabbit	Polyclonal	Human	WB	CD41 Antibody LS-C151582 Rabbit Polyclonal 50 µg - 380.00 Applications: WB Epitope: N-Terminus   Reactivity: Hu Format: Unconjugated
CD41	Rat	Monoclonal	Mouse	ELISA, WB	CD41 Antibody LS-C35588 Rat Monoclonal 100 µg - 445.00 Applications: WB, ELISA Epitope:   Reactivity: Mu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA	CD41 Antibody LS-C13322 Mouse Monoclonal 500 µg - 515.00 Applications: ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Bovine	Flo, IHC-Fr, IHC-P, IP	CD41 Antibody LS-C123015 Mouse Monoclonal 250 µg - 460.00 Applications: IHC-Fr, IHC-P, Flo... Epitope:   Reactivity: Bo Format: Unconjugated
CD41	Mouse	Monoclonal	Baboon, Human, Monkey	Flo, IHC-Fr	CD41 Antibody [HIP8] LS-C40969 Mouse Monoclonal (1) 100 µg - 220.00 Applications: IHC-Fr, Flo Epitope:   Reactivity: Ba, Hu, Mo Format: Unconjugated
CD41	Rat	Monoclonal	Mouse	Flo, Func, IHC-Fr, IP	CD41 Antibody LS-C44477 Rat Monoclonal 500 µg - 395.00 Applications: IHC-Fr, Flo, IP... Epitope:   Reactivity: Mu Format: Low Endotoxin
CD41	Rat	Monoclonal	Mouse	Flo, IHC-Fr, IP	CD41 Antibody LS-C44479 Rat Monoclonal 100 µg - 225.00 Applications: IHC-Fr, Flo, IP Epitope:   Reactivity: Mu Format: Unconjugated
CD41	Mouse	Monoclonal	Human, Primate	Flo, IHC-Fr	CD41 Antibody [HIP8] LS-C46084 Mouse Monoclonal 100 µg - 248.00 Applications: IHC-Fr, Flo Epitope:   Reactivity: Hu, Pr Format: Unconjugated
CD41	Mouse	Monoclonal	Human, Primate	Flo, IHC-Fr	CD41 Antibody [HIP2] LS-C46085 Mouse Monoclonal 100 µg - 248.00 Applications: IHC-Fr, Flo Epitope:   Reactivity: Hu, Pr Format: Unconjugated
CD41	Mouse	Monoclonal	Human	IHC-Fr	CD41 Antibody [96.2C1] LS-C96315 Mouse Monoclonal 200 µg - 315.00 Applications: IHC-Fr Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Rat	Monoclonal	Mouse	ELISA, Flo, ICC, IHC-Fr	CD41 Antibody [386629] LS-C35589 Rat Monoclonal 100 µg - 445.00 Applications: IHC-Fr, ICC, Flo... Epitope:   Reactivity: Mu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo, IHC, IP	CD41 Antibody LS-C35590 Mouse Monoclonal 100 µg - 420.00 Applications: IHC, Flo, IP Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo, IF, IHC-Fr	CD41 Antibody LS-C13297 Mouse Monoclonal 100 µg - 385.00 Applications: IHC-Fr, IF, Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA, Flo, IHC-Fr	CD41 Antibody LS-C13309 Mouse Monoclonal 100 µg - 385.00 Applications: IHC-Fr, Flo, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Rat	Monoclonal	Mouse	Flo, IHC-Fr, IP	CD41 Antibody LS-C13282 Rat Monoclonal 100 µg - 345.00 Applications: IHC-Fr, Flo, IP Epitope:   Reactivity: Mu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo, IHC	CD41 Antibody LS-C35591 Mouse Monoclonal 120 tst - 455.00 Applications: IHC, Flo Epitope:   Reactivity: Hu Format: FITC
CD41	Mouse	Monoclonal	Human	Flo, IHC	CD41 Antibody LS-C35592 Mouse Monoclonal 120 tst - 565.00 Applications: IHC, Flo Epitope:   Reactivity: Hu Format: PE
CD41	Mouse	Monoclonal	Human	Flo, IHC-Fr	CD41 Antibody LS-C123016 Mouse Monoclonal 100 µg - 470.00 Applications: IHC-Fr, Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo, IHC-Fr	CD41 Antibody LS-C123017 Mouse Monoclonal 100 µg - 495.00 Applications: IHC-Fr, Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Rat	Monoclonal	Mouse	ELISA, Flo, IP	CD41 Antibody [MWReg30] LS-C106791 Rat Monoclonal (2) 50 µg - 215.00 100 µg - 245.00 500 µg - 360.00 Applications: Flo, IP, ELISA Epitope:   Reactivity: Mu Format: Unconjugated
CD41	Rat	Monoclonal	Mouse	Flo	CD41 Antibody [MWReg30] LS-C105866 Rat Monoclonal (2) 50 µg - 230.00 100 µg - 310.00 200 µg - 375.00 Applications: Flo Epitope:   Reactivity: Mu Format: PE
CD41	Rat	Monoclonal	Mouse	Flo	CD41 Antibody [MWReg30] LS-C105877 Rat Monoclonal (2) 50 µg - 215.00 100 µg - 275.00 500 µg - 370.00 Applications: Flo Epitope:   Reactivity: Mu Format: FITC
CD41	Rat	Monoclonal	Mouse	Flo	CD41 Antibody [MWReg30] LS-C106736 Rat Monoclonal (2) 50 µg - 210.00 100 µg - 260.00 500 µg - 340.00 Applications: Flo Epitope:   Reactivity: Mu Format: Biotin
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody [HIP8] LS-C106023 Mouse Monoclonal (1) 25 tst - 215.00 100 tst - 295.00 Applications: Flo Epitope:   Reactivity: Hu Format: FITC
CD41	Rat	Monoclonal	Mouse	Flo	CD41 Antibody [MWReg30] LS-C107285 Rat Monoclonal (1) 25 µg - 230.00 100 µg - 360.00 Applications: Flo Epitope:   Reactivity: Mu Format: APC
CD41	Rat	Monoclonal	Mouse	Flo	CD41 Antibody [MWReg30] LS-C107345 Rat Monoclonal (1) 25 µg - 215.00 100 µg - 360.00 Applications: Flo Epitope:   Reactivity: Mu Format: Cy7, PE
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody [HIP8] LS-C106339 Mouse Monoclonal (1) 25 tst - 230.00 100 tst - 325.00 Applications: Flo Epitope:   Reactivity: Hu Format: PE
CD41	Mouse	Monoclonal	Baboon, Human, Mink	Flo, WB	CD41 Antibody LS-C45124 Mouse Monoclonal 1000 µg - 575.00 Applications: WB, Flo Epitope:   Reactivity: Ba, Hu, Mi Format: Azide-free
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody [MEM-06] LS-C45949 Mouse Monoclonal 100 µg - 241.00 Applications: Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Rat	Monoclonal	Mouse	Flo	CD41 Antibody LS-C44478 Rat Monoclonal 100 µg - 225.00 Applications: Flo Epitope:   Reactivity: Mu Format: FITC
CD41	Rat	Monoclonal	Mouse	Flo	CD41 Antibody LS-C44480 Rat Monoclonal 100 tst - 320.00 Applications: Flo Epitope:   Reactivity: Mu Format: RPE
CD41	Mouse	Monoclonal	Baboon, Human, Mink	Flo	CD41 Antibody LS-C45120 Mouse Monoclonal 100 µg - 310.00 Applications: Flo Epitope:   Reactivity: Ba, Hu, Mi Format: FITC
CD41	Mouse	Monoclonal	Baboon, Human, Mink	Flo	CD41 Antibody LS-C45121 Mouse Monoclonal 200 µg - 335.00 Applications: Flo Epitope:   Reactivity: Ba, Hu, Mi Format: Unconjugated
CD41	Rat	Monoclonal	Mouse	Flo	CD41 Antibody LS-C44476 Rat Monoclonal 100 µg - 215.00 Applications: Flo Epitope:   Reactivity: Mu Format: Biotin
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody [HIP8] LS-C106669 Mouse Monoclonal 25 µg - 190.00 100 µg - 225.00 Applications: Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody [HIP2] LS-C106316 Mouse Monoclonal 25 tst - 215.00 Applications: Flo Epitope:   Reactivity: Hu Format: FITC
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody [96.2C1] LS-C140486 Mouse Monoclonal 100 µg - 270.00 Applications: Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody [96.2C1] LS-C134429 Mouse Monoclonal 100 µg - 295.00 Applications: Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody [96.2C1] LS-C134430 Mouse Monoclonal 100 µg - 340.00 Applications: Flo Epitope:   Reactivity: Hu Format: Biotin
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody [96.2C1] LS-C134431 Mouse Monoclonal 120 tst - 340.00 Applications: Flo Epitope:   Reactivity: Hu Format: FITC
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody [96.2C1] LS-C134432 Mouse Monoclonal 120 tst - 455.00 Applications: Flo Epitope:   Reactivity: Hu Format: RPE
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody [96.2C1] LS-C134433 Mouse Monoclonal 100 µg - 295.00 Applications: Flo Epitope:   Reactivity: Hu Format: Azide-free
CD41	Mouse	Monoclonal	Human		CD41 Antibody [MEM-06] LS-C46213 Mouse Monoclonal 100 tst - 304.00 Applications: Epitope:   Reactivity: Hu Format: APC
CD41	Mouse	Monoclonal	Human		CD41 Antibody [MEM-06] LS-C46249 Mouse Monoclonal 100 tst - 276.00 Applications: Epitope:   Reactivity: Hu Format: FITC
CD41	Mouse	Monoclonal	Human		CD41 Antibody [MEM-06] LS-C46304 Mouse Monoclonal 100 µg - 276.00 Applications: Epitope:   Reactivity: Hu Format: Biotin
CD41	Mouse	Monoclonal	Human		CD41 Antibody [MEM-06] LS-C46486 Mouse Monoclonal 100 tst - 304.00 Applications: Epitope:   Reactivity: Hu Format: PE
CD41	Mouse	Monoclonal	Human		CD41 Antibody [96.2C1] LS-C86803 Mouse Monoclonal 100 µg - 530.00 Applications: Epitope:   Reactivity: Hu Format: Biotin
CD41	Mouse	Monoclonal	Human	Flo, Func, ICC, IP	CD41 Antibody [Gi5] LS-C35601 Mouse Monoclonal 100 µg - 420.00 Applications: ICC, Flo, IP... Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA, Flo, IF	CD41 Antibody LS-C35596 Mouse Monoclonal 100 tst - 495.00 Applications: IF, Flo, ELISA Epitope:   Reactivity: Hu Format: PE
CD41	Mouse	Monoclonal	Human	IP, WB	CD41 Antibody LS-C13329 Mouse Monoclonal 100 µg - 420.00 Applications: WB, IP Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA, WB	CD41 Antibody LS-C78556 Mouse Monoclonal 500 µg - 490.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA, WB	CD41 Antibody LS-C78557 Mouse Monoclonal 500 µg - 490.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA, Flo	CD41 Antibody LS-C13301 Mouse Monoclonal 100 µg - 385.00 Applications: Flo, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA, Flo	CD41 Antibody LS-C13302 Mouse Monoclonal 50 tst - 405.00 Applications: Flo, ELISA Epitope:   Reactivity: Hu Format: FITC
CD41	Mouse	Monoclonal	Human	ELISA, Flo	CD41 Antibody LS-C13303 Mouse Monoclonal 50 tst - 430.00 Applications: Flo, ELISA Epitope:   Reactivity: Hu Format: PE
CD41	Mouse	Monoclonal	Human	ELISA, Flo	CD41 Antibody LS-C13304 Mouse Monoclonal 50 tst - 455.00 Applications: Flo, ELISA Epitope:   Reactivity: Hu Format: Cy5, PE
CD41	Mouse	Monoclonal	Human	ELISA, Flo	CD41 Antibody LS-C13305 Mouse Monoclonal 100 µg - 385.00 Applications: Flo, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA, Flo	CD41 Antibody LS-C13306 Mouse Monoclonal 50 tst - 405.00 Applications: Flo, ELISA Epitope:   Reactivity: Hu Format: FITC
CD41	Mouse	Monoclonal	Human	ELISA, Flo	CD41 Antibody LS-C13307 Mouse Monoclonal 50 tst - 430.00 Applications: Flo, ELISA Epitope:   Reactivity: Hu Format: PE
CD41	Mouse	Monoclonal	Human	ELISA, Flo	CD41 Antibody LS-C13308 Mouse Monoclonal 50 tst - 455.00 Applications: Flo, ELISA Epitope:   Reactivity: Hu Format: Cy5, PE
CD41	Mouse	Monoclonal	Human	ELISA, Flo	CD41 Antibody LS-C13310 Mouse Monoclonal 50 tst - 405.00 Applications: Flo, ELISA Epitope:   Reactivity: Hu Format: FITC
CD41	Mouse	Monoclonal	Human	ELISA, Flo	CD41 Antibody LS-C13311 Mouse Monoclonal 50 tst - 430.00 Applications: Flo, ELISA Epitope:   Reactivity: Hu Format: PE
CD41	Mouse	Monoclonal	Human	ELISA, Flo	CD41 Antibody LS-C13312 Mouse Monoclonal 50 tst - 455.00 Applications: Flo, ELISA Epitope:   Reactivity: Hu Format: Cy5, PE
CD41	Mouse	Monoclonal	Human	ELISA, WB	CD41 Antibody LS-C13323 Mouse Monoclonal 500 µg - 470.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA, WB	CD41 Antibody LS-C13324 Mouse Monoclonal 500 µg - 470.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA, WB	CD41 Antibody LS-C13326 Mouse Monoclonal 500 µg - 470.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo, Func	CD41 Antibody [M148] LS-C13317 Mouse Monoclonal 200 µg - 585.00 Applications: Flo, Func Epitope:   Reactivity: Hu Format: PE
CD41	Mouse	Monoclonal	Human	ELISA, WB	CD41 Antibody LS-C13319 Mouse Monoclonal 500 µg - 470.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA, WB	CD41 Antibody LS-C13320 Mouse Monoclonal 500 µg - 470.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	ELISA, WB	CD41 Antibody LS-C13321 Mouse Monoclonal 500 µg - 470.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo, IF	CD41 Antibody LS-C127668 Mouse Monoclonal 1000 µl - 565.00 Applications: IF, Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo, IF	CD41 Antibody LS-C127670 Mouse Monoclonal 1000 µl - 420.00 Applications: IF, Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo, IF	CD41 Antibody LS-C127671 Mouse Monoclonal 1000 µl - 420.00 Applications: IF, Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Bovine	Flo	CD41 Antibody LS-C127666 Mouse Monoclonal 100 tst - 530.00 Applications: Flo Epitope:   Reactivity: Bo Format: PE
CD41	Mouse	Monoclonal	Baboon, Human	Flo	CD41 Antibody LS-C127667 Mouse Monoclonal 100 µg - 350.00 Applications: Flo Epitope:   Reactivity: Ba, Hu Format: Unconjugated
CD41	Rat	Monoclonal	Mouse	Flo	CD41 Antibody LS-C13328 Rat Monoclonal 100 µg - 335.00 Applications: Flo Epitope:   Reactivity: Mu Format: Biotin
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody LS-C13315 Mouse Monoclonal 200 µg - 525.00 Applications: Flo Epitope:   Reactivity: Hu Format: Biotin
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody LS-C13316 Mouse Monoclonal 200 µg - 510.00 Applications: Flo Epitope:   Reactivity: Hu Format: FITC
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody LS-C13298 Mouse Monoclonal 50 tst - 405.00 Applications: Flo Epitope:   Reactivity: Hu Format: FITC
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody LS-C13299 Mouse Monoclonal 50 tst - 430.00 Applications: Flo Epitope:   Reactivity: Hu Format: PE
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody LS-C13300 Mouse Monoclonal 50 tst - 455.00 Applications: Flo Epitope:   Reactivity: Hu Format: Cy5, PE
CD41	Rat	Monoclonal	Mouse	Flo	CD41 Antibody LS-C13283 Rat Monoclonal 100 µg - 345.00 Applications: Flo Epitope:   Reactivity: Mu Format: FITC
CD41	Rat	Monoclonal	Mouse	Flo	CD41 Antibody LS-C13284 Rat Monoclonal 1000 µl - 390.00 Applications: Flo Epitope:   Reactivity: Mu Format: PE
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody LS-C13289 Mouse Monoclonal 200 µg - 460.00 Applications: Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody LS-C13291 Mouse Monoclonal 1000 µg - 717.00 Applications: Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human, Monkey	Flo	CD41 Antibody LS-C13293 Mouse Monoclonal 100 µg - 435.00 Applications: Flo Epitope:   Reactivity: Hu, Mo Format: FITC
CD41	Mouse	Monoclonal	Human, Monkey	Flo	CD41 Antibody LS-C13295 Mouse Monoclonal 100 tst - 445.00 Applications: Flo Epitope:   Reactivity: Hu, Mo Format: PE
CD41	Mouse	Monoclonal	Human	Flo	CD41 Antibody LS-C78551 Mouse Monoclonal 100 µg - 375.00 Applications: Flo Epitope:   Reactivity: Hu Format: Unconjugated
CD41	Mouse	Monoclonal	Human	IF	CD41 Antibody LS-C13276 Mouse Monoclonal 100 tst - 460.00 Applications: IF Epitope:   Reactivity: Hu Format: FITC

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CD41 Feature Table

Feature Type	Location	Details
Disease	1 - 1039	Defects in ITGA2B are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.
Function	1 - 1039	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Modification	891 - 891	Pyrrolidone carboxylic acid; in light chain form 1.
Molecular Weight	1 - 1039	113377
Similarity	1 - 1039	Belongs to the integrin alpha chain family.
Similarity	1 - 1039	Contains 7 FG-GAP repeats.
Subcellular Location	1 - 1039	Membrane; Single-pass type I membrane protein.
Subunit	1 - 1039	Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181.
Tissue Specificity	1 - 1039	Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.

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