LSBio The Immunohistochemistry Antibody Company
  • Home
  • Products
    • All Antibodies
    • IHC-plus Antibodies
  • Services
    • Immunohistochemistry Studies
    • Tissue Cross-Reactivity Screening
  • Distributors
  • Resources
    • About our Tissue Bank
    • Customer Support
    • How to Buy
    • IHC-plus Protocol
    • LSBio Media
    • Publications
    • Antibody Reports
  • Company
    • About LifeSpan
    • Press Releases
    • Holiday Schedule
    • Contact Us
  • View Cart

CASP8 / Caspase 8 Antibodies

caspase 8, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis.

Gene Name: caspase 8, apoptosis-related cysteine peptidase
Family/Subfamily: Protease , Cysteine C14
Synonyms: CASP8 Antibody, ALPS2B Antibody, Apoptotic protease Mch-5 Antibody, Apoptotic cysteine protease Antibody, Casp-8 Antibody, Caspase-8 Antibody, CAP4 Antibody, Caspase 8 Antibody, MACH Antibody, MCH5 Antibody, MORT1-associated ced-3 homolog Antibody, ICE-like apoptotic protease 5 Antibody, Pro Caspase 8 Antibody, FADD-like ICE Antibody, FLICE Antibody, MACH-alpha-1/2/3 protein Antibody, MACH-beta-1/2/3/4 protein Antibody
Target Sequences: NM_001228 AAC50645.1 Q14790
 CASP8 / Caspase 8 Feature Table
Featured Image

Featured CASP8 / Caspase 8 Antibody

LS-B3796 is a rabbit polyclonal antibody that LifeSpan has tested extensively in immunohistochemistry (IHC) and is an excellent antibody for use in formalin-fixed paraffin embedded tissues. Multiple tissues were immunolabeled and the results were interpreted by a LifeSpan pathologist. This image shows an example of staining in formalin-fixed paraffin embedded tissue. Learn more about our IHC Validation procedure. All LSBio antibodies are 100% guaranteed.

Publications (1)

1
Prolonged low-dose administration of the cyclooxygenase-2 inhibitor celecoxib enhances the antitumor activity of irinotecan against neuroblastoma xenografts. Kaneko M, Kaneko S, Suzuki K. Cancer science. 2009 100:2193-201. (WB) [PubMed:19673886]

CASP8 / Caspase 8 Antibodies (51)

Target Host Clonality Format Epitope Reactivity Applications
CASP8 / Caspase 8 Rabbit Polyclonal Human, Mouse, Rat ICC, IHC-P, WB
CASP8 / Caspase 8 Antibody LS-B3796 Rabbit Polyclonal thumb(4)
50 µg - 385.00
Applications: IHC-P, ICC, WB Epitope: C-Terminus  
Reactivity: Hu, Mu, Rt Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human, Mouse IHC-P, WB
CASP8 / Caspase 8 Antibody LS-B3797 Rabbit Polyclonal thumb(3)
50 µg - 385.00
Applications: IHC-P, WB Epitope:  
Reactivity: Hu, Mu Format:  
CASP8 / Caspase 8 Rat Monoclonal Human IHC-P, WB
CASP8 / Caspase 8 Antibody [1H10] LS-B4061 Rat Monoclonal thumb(3)
50 µg - 385.00
Applications: IHC-P, WB Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human IHC-P, WB
CASP8 / Caspase 8 Antibody [FLICE 4-1-20] LS-B240 Mouse Monoclonal thumb(1)
50 µl - 385.00
Applications: IHC-P, WB Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human IHC-P, IP, WB
CASP8 / Caspase 8 Antibody LS-B2225 Rabbit Polyclonal thumb(1)
50 µl - 385.00
Applications: IHC-P, WB, IP Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human Flo, IF, IHC-P, WB
CASP8 / Caspase 8 Antibody LS-C99287 Rabbit Polyclonal thumb(5)
100 µg - 290.00
Applications: IHC-P, IF, WB... Epitope: C-Terminus  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Gerbil, Human, Mouse, Rat IHC-Fr, IHC-P, IP, WB
CASP8 / Caspase 8 Antibody LS-C148245 Rabbit Polyclonal thumb(2)
50 µl - 295.00
Applications: IHC-Fr, IHC-P, WB... Epitope:  
Reactivity: Gb, Hu, Mu ... Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human, Monkey, Mouse, Rat ELISA, Flo, IHC, WB
CASP8 / Caspase 8 Antibody [1H11] LS-C169428 Mouse Monoclonal thumb(5)
100 µl - 350.00
Applications: IHC, WB, Flo... Epitope:  
Reactivity: Hu, Mo, Mu ... Format:  
CASP8 / Caspase 8 Rabbit Monoclonal Human ICC, IHC-P, WB
CASP8 / Caspase 8 Antibody [EPR162] LS-C138389 Rabbit Monoclonal thumb(5)
100 µl - 415.00
Applications: IHC-P, ICC, WB Epitope: Internal  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Gerbil, Human, Mouse, Rat IHC-Fr, IHC-P, IP, WB
CASP8 / Caspase 8 Antibody LS-C148246 Rabbit Polyclonal thumb(1)
50 µl - 295.00
Applications: IHC-Fr, IHC-P, WB... Epitope:  
Reactivity: Gb, Hu, Mu ... Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human ICC, IHC-P, WB
CASP8 / Caspase 8 Antibody LS-C185386 Rabbit Polyclonal thumb(3)
100 µl - 335.00
Applications: IHC-P, ICC, WB Epitope: aa1-217  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Monoclonal Human Flo, IHC-P, IP, WB
CASP8 / Caspase 8 Antibody [E6] LS-C49354 Rabbit Monoclonal thumb(2)
100 µl - 415.00
Applications: IHC-P, WB, Flo... Epitope: N-Terminus  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human, Rat IHC, WB
CASP8 / Caspase 8 Antibody LS-C176266 Rabbit Polyclonal thumb(2)
100 µl - 345.00
Applications: IHC, WB Epitope: Thr341  
Reactivity: Hu, Rt Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human IHC, WB
CASP8 / Caspase 8 Antibody LS-C48216 Rabbit Polyclonal thumb(1)
100 µg - 385.00
Applications: IHC, WB Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human, Mouse, Rat IHC-P, IP, WB
CASP8 / Caspase 8 Antibody LS-C77914 Rabbit Polyclonal
500 µl - 495.00
Applications: IHC-P, WB, IP Epitope:  
Reactivity: Hu, Mu, Rt Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human IP, WB
CASP8 / Caspase 8 Antibody [5D3] LS-C179790 Mouse Monoclonal thumb(3)
100 µg - 335.00
Applications: WB, IP Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human Flo, WB
CASP8 / Caspase 8 Antibody [90A992] LS-C507 Mouse Monoclonal thumb(2)
100 µg - 345.00
Applications: WB, Flo Epitope: aa217-222  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Monoclonal Human Flo, IP, WB
CASP8 / Caspase 8 Antibody [E7] LS-C49355 Rabbit Monoclonal thumb(1)
100 µl - 415.00
Applications: WB, Flo, IP Epitope: N-Terminus  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human ELISA, WB
CASP8 / Caspase 8 Antibody LS-C121055 Rabbit Polyclonal thumb(1)
100 µg - 295.00
Applications: WB, ELISA Epitope: C-Terminus  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human ELISA, WB
CASP8 / Caspase 8 Antibody LS-C136944 Rabbit Polyclonal thumb(1)
100 µl - 255.00
Applications: WB, ELISA Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Bovine, Human, Monkey, Mouse, Rat WB
CASP8 / Caspase 8 Antibody LS-C48132 Rabbit Polyclonal thumb(1)
100 µg - 415.00
Applications: WB Epitope:  
Reactivity: Bo, Hu, Mo ... Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human WB
CASP8 / Caspase 8 Antibody LS-C26655 Mouse Monoclonal thumb(1)
100 µg - 330.00
Applications: WB Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human WB
CASP8 / Caspase 8 Antibody LS-C26656 Mouse Monoclonal thumb(1)
100 µg - 330.00
Applications: WB Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Bovine, Dog, Human, Mouse, Pig, Rat WB
CASP8 / Caspase 8 Antibody LS-C31148 Rabbit Polyclonal thumb(1)
100 µg - 335.00
Applications: WB Epitope: N-Terminus  
Reactivity: Bo, Do, Hu ... Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human WB
CASP8 / Caspase 8 Antibody LS-C159265 Mouse Monoclonal thumb(1)
100 µl - 290.00
Applications: WB Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human WB
CASP8 / Caspase 8 Antibody [5F7] LS-C179764 Mouse Monoclonal thumb(1)
100 µg - 335.00
Applications: WB Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human, Mouse, Rat WB
CASP8 / Caspase 8 Antibody LS-C172108 Rabbit Polyclonal thumb(1)
100 µg - 260.00
Applications: WB Epitope: Internal  
Reactivity: Hu, Mu, Rt Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human IP, WB
CASP8 / Caspase 8 Antibody LS-C48276 Mouse Monoclonal
100 µg - 485.00
Applications: WB, IP Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human IP, WB
CASP8 / Caspase 8 Antibody [8CSP03] LS-C87567 Mouse Monoclonal
20 µg - 330.00
100 µg - 555.00
200 µg - 730.00
Applications: WB, IP Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human IP, WB
CASP8 / Caspase 8 Antibody [8CSP03] LS-C87568 Mouse Monoclonal
100 µg - 595.00
200 µg - 790.00
Applications: WB, IP Epitope:  
Reactivity: Hu Format: Azide-free  
CASP8 / Caspase 8 Rabbit Polyclonal Human DB, ELISA
CASP8 / Caspase 8 Antibody LS-C149227 Rabbit Polyclonal
200 µg - 350.00
Applications: DB, ELISA Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Chimpanzee, Human, Monkey ELISA
CASP8 / Caspase 8 Antibody [90A992] LS-C148124 Mouse Monoclonal
100 µg - 355.00
Applications: ELISA Epitope: aa217-222  
Reactivity: Ch, Hu, Mo Format: Biotin  
CASP8 / Caspase 8 Rabbit Polyclonal Mouse, Rat WB
CASP8 / Caspase 8 Antibody LS-C48277 Rabbit Polyclonal
100 µg - 425.00
Applications: WB Epitope:  
Reactivity: Mu, Rt Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human, Mouse, Rat IP
CASP8 / Caspase 8 Antibody LS-C172109 Rabbit Polyclonal
100 µg - 325.00
Applications: IP Epitope: Internal  
Reactivity: Hu, Mu, Rt Format: Magnetic beads  
CASP8 / Caspase 8 Rabbit Polyclonal Human WB
CASP8 / Caspase 8 Antibody LS-C175863 Rabbit Polyclonal
100 µl - 345.00
Applications: WB Epitope: pThr341  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human WB
CASP8 / Caspase 8 Antibody LS-C175879 Rabbit Polyclonal
100 µl - 345.00
Applications: WB Epitope: Thr341  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human, Mouse, Rat IP
CASP8 / Caspase 8 Antibody LS-C171973 Rabbit Polyclonal
100 µg - 325.00
Applications: IP Epitope: Internal  
Reactivity: Hu, Mu, Rt Format: Sepharose  
CASP8 / Caspase 8 Rabbit Polyclonal Bovine, Human, Monkey, Mouse, Rat
CASP8 / Caspase 8 Antibody LS-C95930 Rabbit Polyclonal
0.5 ml - 330.00
1 ml - 445.00
Applications: Epitope: N-Terminus  
Reactivity: Bo, Hu, Mo ... Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human ICC, IP, WB
CASP8 / Caspase 8 Antibody LS-C12539 Mouse Monoclonal
50 µg - 395.00
Applications: ICC, WB, IP Epitope: aa181-478  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human ELISA, IP, WB
CASP8 / Caspase 8 Antibody LS-C12543 Mouse Monoclonal
200 µl - 405.00
Applications: WB, IP, ELISA Epitope: C-Terminus  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human ELISA, WB
CASP8 / Caspase 8 Antibody LS-C12544 Mouse Monoclonal
100 µl - 405.00
Applications: WB, ELISA Epitope: N-Terminus  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human IP, WB
CASP8 / Caspase 8 Antibody LS-C12542 Rabbit Polyclonal
200 µg - 495.00
Applications: WB, IP Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human ELISA, WB
CASP8 / Caspase 8 Antibody LS-C12520 Mouse Monoclonal
200 µl - 460.00
Applications: WB, ELISA Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human IP, WB
CASP8 / Caspase 8 Antibody LS-C12525 Mouse Monoclonal
500 µl - 530.00
Applications: WB, IP Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human IP, WB
CASP8 / Caspase 8 Antibody LS-C12534 Mouse Monoclonal
100 µg - 520.00
Applications: WB, IP Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human ELISA, WB
CASP8 / Caspase 8 Antibody LS-C125264 Mouse Monoclonal
50 µl - 365.00
Applications: WB, ELISA Epitope:  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human ELISA, WB
CASP8 / Caspase 8 Antibody LS-C77917 Mouse Monoclonal
100 µg - 510.00
Applications: WB, ELISA Epitope: aa217-222  
Reactivity: Hu Format: Biotin  
CASP8 / Caspase 8 Rabbit Polyclonal Human, Mouse WB
CASP8 / Caspase 8 Antibody LS-C77922 Rabbit Polyclonal
100 µg - 525.00
Applications: WB Epitope: Internal  
Reactivity: Hu, Mu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human, Mouse, Rat WB
CASP8 / Caspase 8 Antibody LS-C77923 Rabbit Polyclonal
100 µg - 590.00
Applications: WB Epitope: C-Terminus  
Reactivity: Hu, Mu, Rt Format:  
CASP8 / Caspase 8 Mouse Monoclonal Human WB
CASP8 / Caspase 8 Antibody LS-C77915 Mouse Monoclonal
100 µg - 510.00
Applications: WB Epitope: aa217-222  
Reactivity: Hu Format:  
CASP8 / Caspase 8 Rabbit Polyclonal Human, Mouse, Rat WB
CASP8 / Caspase 8 Antibody LS-C127263 Rabbit Polyclonal
100 µg - 395.00
Applications: WB Epitope:  
Reactivity: Hu, Mu, Rt Format:  

CASP8 / Caspase 8 Feature Table


Feature Type Location Details
Disease 1 - 479 Defects in CASP8 are the cause of caspase-8 deficiency (CASP8D) [MIM:607271]. CASP8D is a disorder resembling autoimmune lymphoproliferative syndrome (ALPS). It is characterized by lymphadenopathy, splenomegaly, and defective CD95-induced apoptosis of peripheral blood lymphocytes (PBLs). It leads to defects in activation of T-lymphocytes, B-lymphocytes, and natural killer cells leading to immunodeficiency characterized by recurrent sinopulmonary and herpes simplex virus infections and poor responses to immunization.
Function 1 - 479 Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere
Modification 188 - 188 Phosphoserine (By similarity)
Modification 219 - 219 Phosphoserine
Modification 334 - 334 Phosphotyrosine
Molecular Weight 1 - 479 55391
Similarity 1 - 479 Belongs to the peptidase C14A family.
Similarity 1 - 479 Contains 2 DED (death effector) domains.
Subcellular Location 1 - 479 Cytoplasm.
Subunit 1 - 479 Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 10 kDa (p10) subunit. Interacts with FADD, CFLAR and PEA15. Isoform 9 interacts at the endoplasmic reticulum with a complex containing BCAP31, BAP29, BCL2 and/or BCL2L1. Interacts with TNFAIP8L2 (By similarity).
Tissue Specificity 1 - 479 Isoform 1, isoform 5 and isoform 7 are expressed in a wide variety of tissues. Highest expression in peripheral blood leukocytes, spleen, thymus and liver. Barely detectable in brain, testis and skeletal muscle.

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

Copyright © 2013 LifeSpan BioSciences, Inc. All Rights Reserved