Calreticulin Antibodies

calreticulin

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes.

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Calreticulin Antibodies (35)

Target	Host	Clonality	Format	Epitope	Reactivity	Applications
Calreticulin	Mouse	Monoclonal	Human	ELISA, IF, IHC-P, WB	Calreticulin Antibody [1G6A7] LS-B3473 Mouse Monoclonal (3) 50 µl - 385.00 Applications: IHC-P, IF, WB... Epitope:   Reactivity: Hu Format: Unconjugated
Calreticulin	Chicken	Polyclonal	Dog, Hamster, Human, Mouse, Rabbit, Rat	ICC, IF, IHC-P, IP, WB	Calreticulin Antibody LS-B3131 Chicken Polyclonal (2) 50 µl - 385.00 Applications: IHC-P, ICC, IF... Epitope: aa399-414   Reactivity: Do, Ha, Hu ... Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Bovine, Human, Mouse, Rat	ICC, IF, IHC-P, IP, WB	Calreticulin Antibody LS-B274 Rabbit Polyclonal (1) 100 µl - 385.00 Applications: IHC-P, ICC, IF... Epitope:   Reactivity: Bo, Hu, Mu ... Format: Unconjugated
Calreticulin	Mouse	Monoclonal		IHC-P, IP, WB	Calreticulin Antibody [5F12-B10] LS-B3411 Mouse Monoclonal (2) 50 µg - 385.00 Applications: IHC-P, WB, IP Epitope:   Reactivity: Format: Unconjugated
Calreticulin	Sheep	Polyclonal	Dog, Human, Mouse, Rat	IHC-P, IP, WB	Calreticulin Antibody LS-B5223 Sheep Polyclonal (2) 125 µg - 385.00 Applications: IHC-P, WB, IP Epitope:   Reactivity: Do, Hu, Mu ... Format: Unconjugated
Calreticulin	Rabbit	Monoclonal	Human, Mouse, Rat	Flo, ICC, IF, IHC-P, IP, WB	Calreticulin Antibody [EPR3924] LS-B7328 Rabbit Monoclonal (3) 50 µl - 385.00 Applications: IHC-P, ICC, IF... Epitope: Internal   Reactivity: Hu, Mu, Rt Format: Unconjugated
Calreticulin	Mouse	Monoclonal	Human	ELISA, IHC-P, WB	Calreticulin Antibody [1G11-1A9] LS-B5380 Mouse Monoclonal (3) 50 µg - 450.00 Applications: IHC-P, WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Dog, Human, Mouse, Pig, Rabbit, Rat	IHC-P, WB	Calreticulin Antibody LS-B5578 Rabbit Polyclonal (2) 50 µg - 385.00 Applications: IHC-P, WB Epitope: C-Terminus   Reactivity: Do, Hu, Mu ... Format: Unconjugated
Calreticulin	Goat	Polyclonal	Human, Mouse, Rabbit, Rat	IHC-Fr, WB	Calreticulin Antibody LS-C42811 Goat Polyclonal 100 µl - 325.00 Applications: IHC-Fr, WB Epitope:   Reactivity: Hu, Mu, Rb ... Format: Unconjugated
Calreticulin	Mouse	Monoclonal	Human, Mouse	ELISA, IF, IHC, WB	Calreticulin Antibody [1G6A7] LS-C171397 Mouse Monoclonal (4) 100 µl - 370.00 Applications: IHC, IF, WB... Epitope:   Reactivity: Hu, Mu Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human, Mouse, Rat	ELISA, IF, IHC-P, WB	Calreticulin Antibody LS-C118845 Rabbit Polyclonal (3) 100 µg - 295.00 Applications: IHC-P, IF, WB... Epitope: N-Terminus   Reactivity: Hu, Mu, Rt Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human, Mouse	Flo, IHC, WB	Calreticulin Antibody LS-C168281 Rabbit Polyclonal (3) 100 µg - 290.00 Applications: IHC, WB, Flo Epitope:   Reactivity: Hu, Mu Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human, Mouse	Flo, IHC, WB	Calreticulin Antibody LS-C168282 Rabbit Polyclonal (3) 100 µg - 290.00 Applications: IHC, WB, Flo Epitope: aa284-313   Reactivity: Hu, Mu Format: Unconjugated
Calreticulin	Rabbit	Monoclonal	Human, Mouse, Rat	ICC, IHC-P, WB	Calreticulin Antibody [EPR3925] LS-C137838 Rabbit Monoclonal (3) 100 µl - 385.00 Applications: IHC-P, ICC, WB Epitope:   Reactivity: Hu, Mu, Rt Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Bovine, Chicken, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep	ICC, IHC, IP, WB	Calreticulin Antibody LS-C109056 Rabbit Polyclonal (1) 50 µl - 180.00 200 µl - 320.00 Applications: IHC, ICC, WB... Epitope:   Reactivity: Bo, Ck, Do ... Format: Unconjugated
Calreticulin	Mouse	Monoclonal	Human	IHC, IP, WB	Calreticulin Antibody LS-C48179 Mouse Monoclonal 100 µg - 455.00 Applications: IHC, WB, IP Epitope:   Reactivity: Hu Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human, Mouse, Rat	IHC, WB	Calreticulin Antibody LS-C48180 Rabbit Polyclonal 100 µg - 405.00 Applications: IHC, WB Epitope: C-Terminus   Reactivity: Hu, Mu, Rt Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Bovine, Hamster, Human, Mouse, Rat	ICC, IF, IHC, IP, WB	Calreticulin Antibody LS-C21166 Rabbit Polyclonal 100 µl - 460.00 Applications: IHC, ICC, IF... Epitope:   Reactivity: Bo, Ha, Hu ... Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Bovine, Dog, Guinea pig, Hamster, Human, Mouse, Pig, Rabbit, Rat, Sheep	ICC, IHC, IP, WB	Calreticulin Antibody LS-C21171 Rabbit Polyclonal 50 µl - 340.00 Applications: IHC, ICC, WB... Epitope: aa405-417   Reactivity: Bo, Do, Gp ... Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Bovine, Chicken, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rat, Sheep	ICC, IHC, IP, WB	Calreticulin Antibody LS-C122794 Rabbit Polyclonal 100 µl - 415.00 Applications: IHC, ICC, WB... Epitope:   Reactivity: Bo, Ck, Do ... Format: Unconjugated
Calreticulin	Mouse	Monoclonal	Hamster, Human, Monkey	IHC, IP, WB	Calreticulin Antibody LS-C21172 Mouse Monoclonal 50 µg - 375.00 Applications: IHC, WB, IP Epitope:   Reactivity: Ha, Hu, Mo Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human, Rabbit, Rat	IHC, IP, WB	Calreticulin Antibody LS-C21176 Rabbit Polyclonal 100 µl - 580.00 Applications: IHC, WB, IP Epitope:   Reactivity: Hu, Rb, Rt Format: Unconjugated
Calreticulin	Goat	Polyclonal	Human, Mouse, Rabbit, Rat	IHC-Fr, WB	Calreticulin Antibody LS-C21170 Goat Polyclonal 100 µl - 455.00 Applications: IHC-Fr, WB Epitope:   Reactivity: Hu, Mu, Rb ... Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Bovine, Human, Mouse, Pig, Rat, Xenopus	IHC, WB	Calreticulin Antibody LS-C21156 Rabbit Polyclonal 200 µg - 505.00 Applications: IHC, WB Epitope: C-Terminus   Reactivity: Bo, Fr, Hu ... Format: Unconjugated
Calreticulin	Chicken	Polyclonal	Human, Mouse, Rat	IHC-Fr, WB	Calreticulin Antibody LS-C77613 Chicken Polyclonal 100 µl - 510.00 Applications: IHC-Fr, WB Epitope: aa24-43   Reactivity: Hu, Mu, Rt Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human	ELISA, WB	Calreticulin Antibody LS-C82088 Rabbit Polyclonal (1) 50 µg - 475.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
Calreticulin	Mouse	Monoclonal	Human	ELISA, WB	Calreticulin Antibody [1G6A7] LS-C82089 Mouse Monoclonal (1) 100 µg - 475.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human	ELISA, IF	Calreticulin Antibody LS-C172310 Rabbit Polyclonal (1) 100 µl - 345.00 Applications: IF, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human	WB	Calreticulin Antibody LS-C135474 Rabbit Polyclonal (1) 50 µg - 370.00 Applications: WB Epitope: Internal   Reactivity: Hu Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human	WB	Calreticulin Antibody LS-C117077 Rabbit Polyclonal (1) 50 µg - 380.00 Applications: WB Epitope: Internal   Reactivity: Hu Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human, Mouse	WB	Calreticulin Antibody LS-C2540 Rabbit Polyclonal (1) 100 µl - 335.00 Applications: WB Epitope:   Reactivity: Hu, Mu Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Bovine, Dog, Human, Mouse, Pig, Rat	WB	Calreticulin Antibody LS-C30996 Rabbit Polyclonal (1) 100 µg - 335.00 Applications: WB Epitope: C-Terminus   Reactivity: Bo, Do, Hu ... Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human	ELISA, WB	Calreticulin Antibody LS-C41535 Rabbit Polyclonal 100 µl - 298.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Bovine, Chicken, Dog, Guinea pig, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat, Sheep	WB	Calreticulin Antibody LS-C153109 Rabbit Polyclonal 100 µl - 290.00 Applications: WB Epitope:   Reactivity: Bo, Ck, Do ... Format: Unconjugated
Calreticulin	Rabbit	Polyclonal	Human, Mouse	WB	Calreticulin Antibody LS-C77617 Rabbit Polyclonal 50 µl - 445.00 Applications: WB Epitope:   Reactivity: Hu, Mu Format: Unconjugated

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Calreticulin Feature Table

Feature Type	Location	Details
Function	1 - 417	Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export.
Modification	48 - 48	N6-acetyllysine
Modification	159 - 159	N6-acetyllysine
Modification	209 - 209	N6-acetyllysine
Molecular Weight	1 - 417	48142
Similarity	1 - 417	Belongs to the calreticulin family.
Subcellular Location	1 - 417	Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.
Subunit	1 - 417	Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 (By similarity). Interacts with NR3C1 and TRIM21.

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