ATF6 Antibodies

activating transcription factor 6

Activating Transcription Factor 6 (ATF6) is a type II transmembrane glycoprotein located on the ER membrane. In response to ER stress ATF6 is cleaved and the N-terminus including the leucine zipper (which faces the cytosol) moves to the nucleus. Once in the nucleus ATF6 binds to the ER stress response elements in ER stress genes. Site-1 and site-2 protease enzymes that process sterol regulatory binding proteins in response to cholesterol derivation cleave ATF6.

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ATF6 Antibodies (22)

Target	Host	Clonality	Format	Epitope	Reactivity	Applications
ATF6	Mouse	Monoclonal	Hamster, Human, Mouse, Rat	ChrIP, ICC, IHC-P, WB	ATF6 Antibody [70B1413.1] LS-B2564 Mouse Monoclonal (3) 50 µg - 385.00 Applications: IHC-P, ICC, WB... Epitope: aa1-273   Reactivity: Ha, Hu, Mu ... Format: Unconjugated
ATF6	Rabbit	Polyclonal	Human, Mouse	ICC, IHC-P, WB	ATF6 Antibody LS-B2516 Rabbit Polyclonal (1) 50 µg - 385.00 Applications: IHC-P, ICC, WB Epitope: C-Terminus   Reactivity: Hu, Mu Format: Unconjugated
ATF6	Rabbit	Polyclonal	Human, Mouse	ELISA, ICC, IHC-P, WB	ATF6 Antibody LS-B2430 Rabbit Polyclonal (2) 50 µg - 385.00 Applications: IHC-P, ICC, WB... Epitope: N-Terminus   Reactivity: Hu, Mu Format: Unconjugated
ATF6	Rabbit	Polyclonal	Human, Mouse	IHC-P, WB	ATF6 Antibody LS-B5587 Rabbit Polyclonal (2) 50 µg - 385.00 Applications: IHC-P, WB Epitope: C-Terminus   Reactivity: Hu, Mu Format: Unconjugated
ATF6	Mouse	Monoclonal	Human	ELISA, IHC-P, WB	ATF6 Antibody [3D5] LS-B6032 Mouse Monoclonal (1) 50 µg - 450.00 Applications: IHC-P, WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
ATF6	Goat	Polyclonal	Human	ELISA, IHC-P	ATF6 Antibody LS-B2388 Goat Polyclonal (1) 50 µg - 385.00 Applications: IHC-P, ELISA Epitope: C-Terminus   Reactivity: Hu Format: Unconjugated
ATF6	Rabbit	Polyclonal	Human	Flo, IHC, WB	ATF6 Antibody LS-C156565 Rabbit Polyclonal (3) 100 µg - 290.00 Applications: IHC, WB, Flo Epitope: aa356-386   Reactivity: Hu Format: Unconjugated
ATF6	Rabbit	Polyclonal	Human, Mouse, Rat	WB	ATF6 Antibody LS-C171661 Rabbit Polyclonal (2) 100 µg - 260.00 Applications: WB Epitope: N-Terminus   Reactivity: Hu, Mu, Rt Format: Unconjugated
ATF6	Rabbit	Polyclonal	Human	ICC, WB	ATF6 Antibody LS-C180124 Rabbit Polyclonal (1) 100 µl - 335.00 Applications: ICC, WB Epitope:   Reactivity: Hu Format: Unconjugated
ATF6	Rabbit	Polyclonal	Human	ELISA, WB	ATF6 Antibody LS-C136870 Rabbit Polyclonal (1) 100 µl - 255.00 Applications: WB, ELISA Epitope:   Reactivity: Hu Format: Unconjugated
ATF6	Rabbit	Polyclonal	Human	WB	ATF6 Antibody LS-C109612 Rabbit Polyclonal (1) 50 µg - 370.00 Applications: WB Epitope: N-Terminus   Reactivity: Hu Format: Unconjugated
ATF6	Mouse	Monoclonal	Human	DB, ICC	ATF6 Antibody [47C6a] LS-C184793 Mouse Monoclonal 50 µg - 335.00 Applications: ICC, DB Epitope:   Reactivity: Hu Format:
ATF6	Rabbit	Polyclonal	Human	ELISA	ATF6 Antibody LS-C148046 Rabbit Polyclonal 100 µl - 275.00 Applications: ELISA Epitope: aa635-647   Reactivity: Hu Format: Unconjugated
ATF6	Rabbit	Polyclonal	Human, Mouse, Rat	ELISA	ATF6 Antibody LS-C148049 Rabbit Polyclonal 100 µl - 275.00 Applications: ELISA Epitope: aa491-509   Reactivity: Hu, Mu, Rt Format: Unconjugated
ATF6	Rabbit	Polyclonal	Human	ICC	ATF6 Antibody LS-C180692 Rabbit Polyclonal 100 µl - 365.00 Applications: ICC Epitope:   Reactivity: Hu Format: Biotin
ATF6	Rabbit	Polyclonal	Human	ICC	ATF6 Antibody LS-C180693 Rabbit Polyclonal 100 µl - 365.00 Applications: ICC Epitope:   Reactivity: Hu Format: DY650
ATF6	Rabbit	Polyclonal	Human	ICC	ATF6 Antibody LS-C180694 Rabbit Polyclonal 100 µl - 365.00 Applications: ICC Epitope:   Reactivity: Hu Format: DY488
ATF6	Rabbit	Polyclonal	Human	ICC	ATF6 Antibody LS-C180695 Rabbit Polyclonal 100 µl - 365.00 Applications: ICC Epitope:   Reactivity: Hu Format: DY550
ATF6	Rabbit	Polyclonal	Human, Mouse, Rat	IP	ATF6 Antibody LS-C171662 Rabbit Polyclonal 100 µg - 325.00 Applications: IP Epitope: N-Terminus   Reactivity: Hu, Mu, Rt Format: Magnetic beads
ATF6	Rabbit	Polyclonal	Human, Mouse, Rat	IP	ATF6 Antibody LS-C171663 Rabbit Polyclonal 100 µg - 325.00 Applications: IP Epitope: N-Terminus   Reactivity: Hu, Mu, Rt Format: Sepharose
ATF6	Rabbit	Polyclonal	Human, Mouse, Rat	WB	ATF6 Antibody LS-C126587 Rabbit Polyclonal 100 µg - 410.00 Applications: WB Epitope: N-Terminus   Reactivity: Hu, Mu, Rt Format: Unconjugated
ATF6	Rabbit	Polyclonal	Human, Mouse	WB	ATF6 Antibody LS-C3517 Rabbit Polyclonal 100 µg - 450.00 Applications: WB Epitope: C-Terminus   Reactivity: Hu, Mu Format: Unconjugated

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ATF6 Feature Table

Feature Type	Location	Details
Function	1 - 670	Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor.
Molecular Weight	1 - 670	74585
Similarity	1 - 670	Belongs to the bZIP family. ATF subfamily.
Similarity	1 - 670	Contains 1 bZIP domain.
Subcellular Location	1 - 670	Endoplasmic reticulum membrane; Single-pass type II membrane protein.
Subcellular Location	1 - 670	Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus. Note=Under ER stress the cleaved N- terminal cytoplasmic domain translocates into the nucleus.
Subunit	1 - 670	Homodimer and heterodimer with ATF6-beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). Interacts also with the transcription factors GTF2I, YY1 and SRF.
Tissue Specificity	1 - 670	Ubiquitous.

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